RHO Mutations (p.W126L and p.A346P) in Two Japanese Families with Autosomal Dominant Retinitis Pigmentosa

Figure 1

Pedigrees of the two Japanese families with RP and amino acid sequence alignment of the rhodopsin in different vertebrate species. (a) and (b) The solid squares (male) and circles (female) represent the affected individuals. The proband of each family is indicated by the arrows. (c) The tryptophan residue at position 126 is highly conserved. The conserved amino acids between the different species are shown in the black boxes. The less and least conserved amino acids are highlighted in the gray or white boxes, respectively.

(a)

(b)

(c)