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Journal of Ophthalmology
Volume 2014, Article ID 291687, 6 pages
Clinical Study

Pulse-Wave Analysis of Optic Nerve Head Circulation Is Significantly Correlated with Kidney Function in Patients with and without Chronic Kidney Disease

1Department of Ophthalmology, Toho University Sakura Medical Center, 564-1 Shimoshizu, Sakura, Chiba 285-8741, Japan
2Cardiovascular Center, Toho University Sakura Medical Center, 564-1 Shimoshizu, Sakura, Chiba 285-8741, Japan

Received 15 August 2013; Accepted 9 December 2013; Published 2 January 2014

Academic Editor: Michel Eid Farah

Copyright © 2014 Tomoaki Shiba et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Aim. To determine whether there is a significant correlation between the optic nerve head (ONH) circulation determined by laser speckle flowgraphy (LSFG) and kidney function. Materials. Seventy-one subjects were investigated. The estimated glomerular filtration rate (GFR) and serum creatinine, cystatin C, and urinary albumin excretion were measured. The ONH circulation was determined by an analysis of the pulse wave of LSFG, and this parameter was named blowout time (BOT). Chronic kidney disease (CKD) was defined to be present when the estimated GFR was <60 mL/min per 1.73 m2. Pearson’s correlation coefficients were used to determine the relationship between the BOT and the kidney function. We also examined whether there were significant differences in all parameters in patients with and without CKD. Results. BOT was significantly correlated with the level of creatinine ( , ), the estimated GFR ( , ), cystatin C ( , ), and urinary albumin excretion ( , ). The BOT level in subjects with CKD was significantly lower than that in subjects without CKD ( ). Conclusion. BOT in ONH by LSFG can detect the organ damage such as kidney dysfunction, CKD.