Research Article
Novel Lutein Loaded Lipid Nanoparticles on Porcine Corneal Distribution
Table 1
Effect of cyclodextrins (CD) on corneal lutein accumulation in combination with NLC*.
| Vehicles | Accumulation rate (μg/g/hr) | Partition coefficient (10−3) | Enhance ratio |
| NLC | 10.6 ± 0.4 | 21.25 ± 0.8 | 1 | NLC + αCD | 12.1 ± 3 | 24.20 ± 6.2 | 1.14 | NLC + βCD | 16.2 ± 9 | 32.40 ± 1.5 | 1.52 | NLC + HEβCD | 16.2 ± 3.5 | 32.45 ± 7.1 | 1.53 | NLC + HPβCD | 19.8 ± 0.2 | 39.80 ± 0.6 | 1.80 |
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The CD and lutein content in the tested vehicles is 0.5% and 2000 μg/g, respectively.
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