Research Article
Novel Lutein Loaded Lipid Nanoparticles on Porcine Corneal Distribution
Table 3
Composition and characteristics of vehicles loaded with lutein
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| | Composition (%) | Vehicles | | NLC | NLC + HPβCD | HPβCD suspension | Aqueous suspension |
| | Lutein/Transcutol | 0.2/19 | 0.2/19 | 0.2/19 | 0.2/19 | | Corn oil | 0.8 | 0.8 | 0.8 | 0.8 | | Capric acid | 1 | 1 | — | — | | Tween 80 | 3 | 3 | — | — | | Span 60 | 2 | 2 | — | — | | HPβCD | — | 2 | 2 | — | | Water | 74 | 72 | 78 | 80 | | Property | | | | | | Mean (nm) | 229.8 ± 65 | 336.8 ± 43 | 1003 ± 403 | 945 ± 186 | | Zeta potential (mV) | −34.3 ± 0.2 | −28.0 ± 0.5 | −38.1 ± 1.2 | −29.2 ± 2.2 | | Entrapment efficiency (%) | 59.0 ± 1.5 | 68.1 ± 3.3 | 0.19 ± 0.01 | 0.06 ± 0.02 | | Partition coefficient (10−3) | 21.25 ± 0.8 | 104.6 ± 0.9 | 6.6 ± 2.5 | 0.3 ± 0.05 |
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The lutein content in all vehicles is 2000 μg/g.
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