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Journal of Ophthalmology
Volume 2014, Article ID 450428, 6 pages
Review Article

Management of Uveitis-Related Choroidal Neovascularization: From the Pathogenesis to the Therapy

Department of Ophthalmology, “Sapienza” University of Rome, Viale del Policlinico 155, 00161 Rome, Italy

Received 21 December 2013; Accepted 10 April 2014; Published 27 April 2014

Academic Editor: Vishali Gupta

Copyright © 2014 Enzo D’Ambrosio et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Inflammatory choroidal neovascularization is a severe but uncommon complication of uveitis, more frequent in posterior uveitis such as punctate inner choroidopathy, multifocal choroiditis, serpiginous choroiditis, and Vogt-Koyanagi-Harada syndrome. Its pathogenesis is supposed to be similar to the wet age related macular degeneration: hypoxia, release of vascular endothelial growth factor, stromal cell derived factor 1-alpha, and other mediators seem to be involved in the uveitis-related choroidal neovascularization. A review on the factors implicated so far in the pathogenesis of inflammatory choroidal neovascularization was performed. Also we reported the success rate of single studies concerning the therapies of choroidal neovascularization secondary to uveitis during the last decade: photodynamic therapy, intravitreal bevacizumab, and intravitreal ranibizumab, besides steroidal and immunosuppressive therapy. Hereby a standardization of the therapeutic approach is proposed.