Research Article

A Delphi Study to Detect Deficiencies and Propose Actions in Real Life Treatment of Neovascular Age-Related Macular Degeneration

Table 1

Final answers for the second Delphi round questionnaires.

QuestionAlmost neverSometimesFrequentlyAlmost always

Diagnosis and initial treatment
(1) Do you consider the metamorphopsia a red flag symptom?0%2%15%83%
(2) Do you consider a strong decrease of VA a key symptom of alert?0%1%22%77%
(3) Do you consider the appearance of a central scotoma a key symptom of alert?0%1%21%78%
(4) Do you consider a macular hemorrhage in a patient with drusen a key symptom of alert?0%1%5%94%
(5) Do you consider the macular edema in a patient with drusen a key symptom of alert?0%0%21%79%
(6) Do you consider the corrected VA an essential initial test?0%1%8%91%
(7) Do you consider the PPBMC an essential initial test? 0%4%9%87%
(8) Do you consider the macular OCT an essential initial test? 0%0%6%94%
(9) Do you consider the FA an essential initial test? 0%18%42%40%
(10) Do you consider the loading doses (3 intravitreal injections) the routine way to begin treatment in all cases?2%7%21%70%
(11) Do you consider the initial loading dose feasible from a socio-sanitary point of view?5%15%46%34%
(12) Do you consider the PRN regimen (1 intravitreal injection + PRN) the routine way to start treatment in all the cases?35%40%18%7%
(13) Do you consider a complete series of diagnostic tests necessary during the loading phase?25%49%12%14%
(14) Do you consider a limited amount of diagnostic testing necessary during the loading phase?7%39%20%34%
(15) Do you consider monthly complete examinations in the PRN regimen feasible in NHS hospitals (Consider “complete examination” VA, OCT PPBMC)?35%48%15%2%
(16) Do you consider monthly complete examinations in the PRN regimen feasible in private hospitals (Consider “complete examination” VA, OCT PPBMC)?8%27%45%20%

Individualized treatment therapy
(17) Do you have in consideration the balance of risk/profit in deciding which guidelines to follow?1%6%57%36%
(18) Do you consider monthly treatment the most suitable regimen?16%21%40%23%
(19) Do you consider monthly treatment feasible in NHS hospitals? 73%22%3%2%
(20) Do you consider monthly treatment feasible in public hospitals?30%37%28%5%
(21) Do you consider the PRN regimen with monthly visits the most suitable practice?2%25%51%22%
(22) Do you consider the PRN regimen with monthly visits feasible in NHS hospitals?32%36%30%2%
(23) Do you consider the PRN regimen with monthly visits feasible in private hospitals?8%24%60%8%
(24) Do you consider the T&E regimen the most suitable practice? 3%53%38%6%
(25) Do you consider the T&E regimen feasible in NHS hospitals?8%38%52%2%
(26) Do you consider the T&E regimen feasible in private hospitals?5%25%58%12%
(27) Do you consider the W&E regimen the most suitable practice?12%56%31%1%
(28) Do you consider the W&E regimen feasible in NHS hospitals?2%26%67%5%
(29) Do you consider the W&E regimen feasible in private hospitals?4%19%69%8%
(30) Do you consider that, in general, most of the patients will be properly treated with seven injections during the first year of the treatment? 0%10%80%10%
(31) Do you consider that, in general, most of the patients will be properly treated with four injections during the second year of the treatment?1%27%52%5%
(32) Do you consider it suitable to perform the intravitreal injection on the same day of the follow-up visit? 3%23%22%52%
(33) Do you consider it feasible to perform the intravitreal injection on the same day of the follow-up visit in NHS hospitals?29%43%14%14%
(34) Do you consider it feasible to perform the intravitreal injection on the same day of the follow-up visit in private hospitals?5%24%42%29%
(35) Aside from the logistical factors, if you have a clean room in the consulting area, would you consider it appropriate to perform an intravitreal injection there?38%19%19%24%
(36) Do you consider performing the intravitreal injection in a clean room as safe as in the operating room? 13%22%32%32%
(37) Do you consider it necessary that the retinal specialist perform himself VA check?25%42%20%13%
(38) Do you consider it necessary that the retinal specialist perform himself the OCT?15%32%27%26%
(39) Do you consider it necessary that the retinal specialist perform himself the FA?12%20%27%41%
(40) Do you consider it necessary that the retinal specialist perform by himself the PPBMC?2%16%24%58%

Nonresponders and referral to general ophthalmologist
(41) Do you consider an absolute nonresponder a patient with worsening VA and OCT macular thickness post-treatment?0%1%44%55%
(42) In the case of a nonresponder, should the checkup interval be reduced to 15 days since the last injection in order to test for a response? 18%48%19%15%
(43) In the case of a nonresponder, should the AGF and ICG be repeated to rule out pathologies such as CP or RAP?0%13%28%59%
(44) Do you consider visual acuity less than 20/400 a criteria to refer the patient to the GO? 13%59%22%6%
(45) Do you consider visual acuity less than 20/200 a criteria to refer the patient to the GO? 42%49%6%3%
(46) Do you consider a fibrosis over 50% of the lesion (disciform scar) criteria to refer the patient to the GO? 7%48%38%7%
(47) Do you consider the absence of retreatment criteria during the last 6 months a criterion to refer the patient to the GO?37%48%15%0%
(48) Do you consider the absence of retreatment criteria during the last 9 months a criterion to refer the patient to the GO?25%34%35%6%
(49) Do you consider the absence of retreatment criteria during the last 12 months a criterion to refer the patient to the GO?13%31%33%23%
(50) How many monthly injections do you usually perform to treat the relapses?At least, a fixed load phase until the criteria of re-treatment disappeared
47%
Only until the criteria of retreatment disappeared
53%
(51) After how many injections do you define a nonresponder?First injection
16%
After the loading phase
60%
After six months of treatment
20%
After first year of treatment
4%
(52) In the case of a nonresponder the second line treatment should be toInterrupt the treatment with anti-VEGF
11%
Change the treatment with other anti-VEGF
42%
Use combined therapy
47%
Use the same treatment
0%

VA: best corrected visual acuity; OCT: optimal coherence tomography; PPBMC: posterior pole biomicroscopy; FA: fluorescein angiography; NHS: National Health System; PRN: pro re nata; T&E: treat and extend; W&E: wait and extend; ICG: indocyanine green angiography; CP: choroidal vascular polidopipathy; RAP: retinal angiomatous proliferation; GO: general ophthalmologist.