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Journal of Ophthalmology
Volume 2014, Article ID 615213, 6 pages
Clinical Study

Interocular Shift of Visual Attention Enhances Stereopsis and Visual Acuities of Anisometropic Amblyopes beyond the Critical Period of Visual Development: A Novel Approach

1Department of Ophthalmology, Eye & ENT Hospital, Fudan University, 83 FenYang Road, Shanghai 200031, China
2Key Laboratory of Myopia, Ministry of Health, Eye & ENT Hospital, Fudan University, 83 FenYang Road, Shanghai 200031, China
3Schepens Eye Research Institute, Massachusetts Eye and Ear, Department of Ophthalmology, Harvard Medical School, Boston, MA 02135, USA
4Department of Internal Medicine, Section of Neurology, Room GF328, Health Sciences Centre, University of Manitoba, 820 Sherbrook Street, Winnipeg MB, Canada R3T 2N2
5Department of Ophthalmology, National Taiwan University Hospital, 7 ZhongShan S Road, Taipei 10002, Taiwan

Received 19 July 2014; Accepted 7 November 2014; Published 15 December 2014

Academic Editor: Terri L. Young

Copyright © 2014 Liwen Huang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Aims. Increasing evidence shows that imbalanced suppressive drive prior to binocular combination may be the key factor in amblyopia. We described a novel binocular approach, interocular shift of visual attention (ISVA), for treatment of amblyopia in adult patients. Methods. Visual stimuli were presented anaglyphically on a computer screen. A square target resembling Landolt C had 2 openings, one in red and one in cyan color. Through blue-red goggles, each eye could only see one of the two openings. The patient was required to report the location of the opening presented to the amblyopic eye. It started at an opening size of 800 sec of arc, went up and down in 160 sec of arc step, and stopped when reaching the 5th reversals. Ten patients with anisometropic amblyopia older than age 14 (average age: 26.7) were recruited and received ISVA treatment for 6 weeks, with 2 training sessions per day. Results. Both Titmus stereopsis () and Random-dot stereopsis were significantly improved. Average improvement in best corrected visual acuity (BCVA) was 0.74 line . Conclusions. The ISVA treatment may be effective in treating amblyopia and restoring stereoscopic function.