Evaluation of Corneal Topography and Biomechanical Parameters after Use of Systemic Isotretinoin in Acne Vulgaris

Table 1

Changes of Schirmer 1 test, anesthetized Schirmer test, and tear break-up time of the patients.

	Baseline	1 month	3 months	6 months	Follow-up
S1T, mm/5 min
Mean ± SD	28.80 ± 2.40	27.60 ± 2.35	26.88 ± 2.08	26.32 ± 1.96	28.78 ± 2.38
		0.132	0.116	0.094	0.854
AST, mm/5 min
Mean ± SD	18.74 ± 3.42	16.96 ± 3.30	15.06 ± 3.13	14.92 ± 3.22	18.72 ± 3.40
		0.044^∤	0.021^∤	0.008^∤	0.564
TBUT, sn
Mean ± SD	14.84 ± 2.11	10.44 ± 2.82	9.86 ± 2.92	9.42 ± 3.11	14.76 ± 2.26
		0.012^∤	0.008^∤	0.006^∤	0.342

, value according to paired -test compared with baseline.
S1T, Schirmer 1 test; AST, anesthetized Schirmer test; TBUT, tear break-up time; SD, standard deviation.
^∤ Statistically significant at the 0.05 level.