Evaluation of Corneal Topography and Biomechanical Parameters after Use of Systemic Isotretinoin in Acne Vulgaris

Table 3

Biomechanical parameters measured with ocular response analyzer and central corneal thickness measured with ultrasonic pachymeter before and after treatment.

	Baseline	1 month	3 months	6 months	Follow-up
CH, mmHg
Mean ± SD	11.67 ± 2.22	11.48 ± 2.13	11.50 ± 2.12	11.51 ± 2.13	11.58 ± 2.18
		0.206	0.289	0.343	0.664
CRF, mmHg
Mean ± SD	11.11 ± 2.33	11.05 ± 2.15	11.43 ± 2.14	10.97 ± 2.08	10.86 ± 2.04
		0.691	0.644	0.535	0.489
CCTusg, µm
Mean ± SD	544.56 ± 46.14	542.18 ± 45.92	540.72 ± 45.94	539.89 ± 45.88	544.53 ± 46.08
		0.547	0.322	0.208	0.782

, value according to paired -test compared with baseline.
CH, corneal hysteresis; CRF, corneal resistance factor; CCT_usg, central corneal thickness measured with ultrasonic pachymeter; SD, standard deviation.