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Journal of Ophthalmology
Volume 2014, Article ID 720385, 6 pages
Clinical Study

Effect on Intraocular Pressure of Switching from Latanoprost and Travoprost Monotherapy to Timolol Fixed Combinations in Patients with Normal-Tension Glaucoma

Department of Ophthalmology and Visual Science, Niigata University Graduate School of Medical and Dental Sciences, 1-757 Asahimachi-dori, Chuo-ku, Niigata 951-8510, Japan

Received 21 September 2014; Revised 9 November 2014; Accepted 9 November 2014; Published 19 November 2014

Academic Editor: Pai-Huei Peng

Copyright © 2014 Ryoko Igarashi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Purpose. To evaluate the effect on intraocular pressure (IOP) of switching from latanoprost and travoprost monotherapy to timolol fixed combinations in Japanese patients with normal-tension glaucoma (NTG). Methods. 27 NTG patients (54 eyes) were compared IOP, superficial punctuate keratitis (SPK) scores, and conjunctival injection scores in eyes treated with prostaglandin (PG) or PG analog/beta-blocker (PG/b) fixed-combination 6 months after the change in therapy. Results. The mean baseline intraocular pressure was  mmHg in eyes receiving PG therapy only and  mmHg in eyes switched to PG/b. Switching to fixed combination therapy from PG monotherapy, the mean IOP was  mmHg   % reduction from baseline) at 6 months. The mean conjunctival injection score was 0.69 for eyes on PG monotherapy and 0.56 for eyes on fixed combination therapy . The mean SPK scores were 0.46 and 0.53. This difference was not statistically significant . Conclusions. Switching from PG monotherapy to PG/b fixed combination therapy for NTG resulted in a greater intraocular pressure reduction than PG alone without increasing the number of instillations.