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Journal of Ophthalmology
Volume 2014, Article ID 820853, 6 pages
Clinical Study

The Association between Diabetic Retinopathy and Levels of Ischemia-Modified Albumin, Total Thiol, Total Antioxidant Capacity, and Total Oxidative Stress in Serum and Aqueous Humor

1Department of Ophthalmology, Cumhuriyet University School of Medicine, 58140 Sivas, Turkey
2Department of Ophthalmology, Ulus State Hospital, Ankara, Turkey
3Department of Biochemistry, Cumhuriyet University School of Medicine, 58140 Sivas, Turkey

Received 24 May 2014; Revised 14 November 2014; Accepted 16 November 2014; Published 16 December 2014

Academic Editor: Tamer A. Macky

Copyright © 2014 Kadir Kirboga et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Purpose. To investigate the oxidant and antioxidant status of patients with type 2 diabetes mellitus and nonproliferative diabetic retinopathy (DRP). Methods. Forty-four patients who had cataract surgery were enrolled in the study. We included 22 patients with DRP in one group and 22 patients in the control group. Samples of aqueous humor and serum were taken from all patients. Serum and aqueous ischemia-modified albumin (IMA), total thiol, total antioxidant capacity (TAC), and total oxidative stress (TOS) levels were compared in two groups. Results. Median serum IMA levels were 44.80 absorbance units in the DRP group and 40.15 absorbance units in the control group (). Median serum total thiol levels in the DRP group were significantly less than those in the control group (3051.13 and 3910.12, resp., ). Mean TOS levels in the serum were 2.93 ± 0.19 in the DRP group and 2.61 ± 0.26 in the control group (). The differences in mean total thiol, TAC, and TOS levels in the aqueous humor and mean TAC levels in the serum were not statistically significant. Conclusion. IMA, total thiol, and TOS levels in the serum might be useful markers in monitoring the risk of DRP development.