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Journal of Ophthalmology
Volume 2014, Article ID 821920, 5 pages
Clinical Study

Long Term Followup of Photorefractive Keratectomy with Adjuvant Use of Mitomycin C

1Department of Ophthalmology, University Hospital of Heraklion, Heraklion, 71100 Crete, Greece
2Bascom Palmer Eye Institute, Miller School of Medicine, University of Miami, Miami, FL 33136, USA

Received 22 November 2013; Accepted 13 March 2014; Published 29 April 2014

Academic Editor: Takeshi Ide

Copyright © 2014 Vasilios F. Diakonis et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Purpose. To study the long term refractive and visual outcomes of photorefractive keratectomy (PRK) with intraoperative application of mitomycin C (MMC). Methods. This study included 37 eyes who received myopic PRK; after photoablation, a sponge soaked in 0.02% MMC solution was applied in all corneas for 2 minutes. Efficacy, safety, predictability, and stability of PRK MMC were evaluated. Endothelial cell density was evaluated at the last postoperative interval. Results. Mean preoperative spherical equivalent (SEQ) was  D (diopters) and reduced to  D at the last postoperative examination. Mean followup was months. All the eyes were in the ±1.00 D of attempted versus achieved SEQ at the one-year follow-up interval. Furthermore, 95% of the eyes did not lose lines or gained 1 to 2 lines of CDVA, while 5% lost 1 line. At the third postoperative month, 89% of the eyes either were clear or had trace haze, while 4 eyes had mild haze; by the 12-month postoperative interval, none of the eyes demonstrated haze. Mean endothelial cell density (ECD) at the last postoperative interval was  cells/mm2. Conclusions. PRK, with intraoperative use of MMC, demonstrates stable refractive and visual outcomes up to 44 months after surgery.