Do Nutritional Supplements Have a Role in Age Macular Degeneration Prevention?

Table 3

Summary of different animal models studied in relation to dietary omega-3 PUFA.

Authors	Animal model	Results
Koto T et al., 2007 (see [92])	C57BL/6 mice	Supplementation with EPA prevented choroidal neovascularization induced after laser photocoagulation
Chan et al., 2008 (see [94])	Cx3cr1 and Ccl2-deficient mice	Smaller number of retinal lesions when diet high in omega-3 PUFA
Tuo et al., 2009 (see [93])	Cx3cr1 and Ccl2-deficient mice	Mice that ingested a high omega-3 PUFA diet showed a slower progression of retinal lesions compared with the low omega-3 PUFA group
Neuringer et al., 2010 (see [100]); Renner et al., 2013 (see [102])	Macaque monkeys	Diets lacking carotenoids and omega-3 PUFAs developed patches of RPE atrophy and increased incidence of drusen. SD-OCT showed RPE disruption