Journal of Ophthalmology

Clinical Study

Clinical Significance of Optic Disc Progression by Topographic Change Analysis Maps in Glaucoma: An 8-Year Follow-Up Study

Table 3

Univariable Cox models for the hazard of glaucoma progression by TCA status and other potential prognostic factors.


Covariate	Stereophotograph and/or Visual Field			Stereophotographs			Visual Fields
Covariate	HR	95% CI		HR	95% CI		HR	95% CI

TCA progression
Stable	1.00			1.00			1.00
Progressed	1.18	(0.39, 3.63)	0.76	0.99	(0.29, 3.36)	0.99	3.70	(0.37, 37.14)	0.27
Sex
Male	1.00			1.00			1.00
Female	1.52	(0.54, 4.33)	0.43	1.53	(0.48, 4.84)	0.47	3.56	(0.39, 32.63)	0.26
MRA at baseline
Within normal limits	1.00			1.00			1.00
Borderline	1.56	(0.36, 6.72)	0.55	2.35	(0.47, 11.73)	0.30	1.02	(0.10, 10.81)	0.99
Outside normal limits	1.05	(0.34, 3.24)	0.94	1.31	(0.33, 5.32)	0.70	0.45	(0.07, 2.76)	0.39
CCT (per 50 μm thicker)	0.85	(0.46, 1.58)	0.61	0.90	(0.47, 1.74)	0.76	0.48	(0.16, 1.44)	0.19
MD at baseline (per 1 dB larger)	1.03	(0.88, 1.21)	0.69	1.08	(0.89, 1.32)	0.43	0.93	(0.75, 1.16)	0.53
PSD at baseline (per 1 dB larger)	1.03	(0.91, 1.17)	0.63	0.99	(0.85, 1.16)	0.92	1.13	(0.94, 1.37)	0.19
VFI at baseline (per 10 units)	0.99	(0.57, 1.73)	0.97	1.11	(0.56, 2.19)	0.77	0.77	(0.33, 1.78)	0.54
Age at baseline (per decade)	1.11	(0.62, 1.97)	0.73	1.13	(0.59, 2.16)	0.70	1.91	(0.54, 6.76)	0.31
Age at enrollment (per decade)	1.12	(0.64, 1.99)	0.68	1.15	(0.61, 2.17)	0.66	1.78	(0.53, 6.01)	0.35
Preenrollment followup (per year)	1.09	(0.78, 1.52)	0.61	1.08	(0.75, 1.55)	0.68	0.88	(0.42, 1.83)	0.73
Vertical c/d ratio at enrollment (per unit)	2.98	(0.16, 57.01)	0.47	3.98	(0.11, 138.27)	0.44	2.95	(0.03, 311.79)	0.65
Mean HRT topography SD at baseline (per 1 µm)	1.04	(0.98, 1.11)	0.17	1.04	(0.97, 1.11)	0.27	1.05	(0.95, 1.15)	0.35

MRA: moorfields regression analysis; OHT: ocular hypertension; CCT: central corneal thickness; MD: mean deviation; PSD: pattern standard deviation; VFI: visual field index; c/d: cup/disc; HR: hazard ratio; SD: standard deviation; CI: confidence interval; dots (.) denote nonestimable quantities.