Safety and Efficacy of Adding Fixed-Combination Brinzolamide/Timolol Maleate to Prostaglandin Therapy for Treatment of Ocular Hypertension or Glaucoma

Table 2

Adverse events (safety population).

	Episodes, (%)
Patients experiencing 1 adverse event, (%)	21 (44.7)
Adverse event severity
Mild	23 (82.1)
Moderate	4 (14.3)
Severe	1 (3.6)
Adverse event
Headache	3 (10.7)
Allergic conjunctivitis	1 (3.6)
Allergic rhinitis	1 (3.6)
Ankle pain	1 (3.6)
Burning/eyelid swelling	1 (3.6)
Blurred vision	1 (3.6)
Conjunctival discomfort	1 (3.6)
Corneal superficial keratitis	1 (3.6)
Crusting of lashes	1 (3.6)
Dry eye	1 (3.6)
Eye pain	1 (3.6)
Lid erythema	1 (3.6)
Metallic taste	1 (3.6)
Ocular foreign body sensation	1 (3.6)
Pseudostenocardia	1 (3.6)
Punctate keratopathy	1 (3.6)
Rhinitis sicca	1 (3.6)
Scheduled knee total endoprosthesis due to; gonarthrosis	1 (3.6)
Stomachache	1 (3.6)
Subjective poorer vision	1 (3.6)
Tinnitus	1 (3.6)
Tiredness and insomnia	1 (3.6)
Trace keratitis	1 (3.6)
Upper respiratory infection	1 (3.6)
Worsening of dorsal pain	1 (3.6)
Unknown	1 (3.6)

Calculated as the percentage of patients in the safety population ().
Serious adverse event.
A description was not available for 1 event in 1 patient.