Effects of Lutein and Zeaxanthin on LPS-Induced Secretion of IL-8 by Uveal Melanocytes and Relevant Signal Pathways

Figure 4

Lutein and zeaxanthin on LPS-induced secretion of IL-8 by uveal melanocytes (UM). Cells were plated into 24-well plates and treated with lutein or zeaxanthin, followed by addition of LPS (0.1 μg/mL) or not. Lutein (a) and zeaxanthin (b) dose-dependently decreased LPS-induced secretion of IL-8 in cultured UM ( as compared with cells treated by 0.1 μg/mL LPS only). IL-8 levels in cells treated with lutein or zeaxanthin and LPS were still greater than those from cells not treated with LPS (), suggesting that both xanthophylls have a partial inhibitory effect on LPS-induced secretion of IL-8.

(a)

(b)