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Journal of Ophthalmology
Volume 2015, Article ID 165475, 7 pages
Research Article

Effects of Long-Term Antiglaucoma Eye Drops on Conjunctival Structures: An In Vivo Confocal Microscopy Study

1Department of Ophthalmology & Visual Science, Eye & ENT Hospital, Shanghai Medical College, Fudan University, Shanghai 200031, China
2State Key Laboratory of Medical Neurobiology, Institutes of Brain Science, Fudan University, Shanghai 200032, China
3Key Laboratory of Myopia, Ministry of Health, Fudan University, Shanghai 200031, China
4Shanghai Key Laboratory of Visual Impairment and Restoration, Fudan University, Shanghai 200032, China

Received 23 March 2015; Revised 21 May 2015; Accepted 1 June 2015

Academic Editor: Lisa Toto

Copyright © 2015 Wenqing Zhu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Purpose. The study was aimed at comparing the long-term effects of different antiglaucoma eye drops on conjunctival structures using laser scanning confocal microscopy. Methods. Eighty patients diagnosed with primary open-angle glaucoma and twenty healthy volunteers were included in this study. The participants were divided into 5 groups according to the different medications. The lachrymal film break-up time, Schirmer’s I test, and Ocular Surface Disease Index Questionnaire were performed in all subjects. The confocal microscopy was used to observe the basal epithelial cell density (ECD), goblet cell density (GCD), dendritic cell density (DCD), and subepithelial collagen fiber diameter (SFD). Results. Statistically significant differences were found among the control group and the antiglaucoma therapy groups in the values of three clinical data (). The GCD, DCD, and SFD showed significant differences in all glaucoma groups when compared to the control (). Moreover, the prostaglandin group differed from the other antiglaucoma therapy groups in the GCD and SFD (). Conclusions. Our study confirmed the significant differences in the conjunctival structures based on the effects of antiglaucoma medications. Less pronounced changes were found in the patients treated with prostaglandin analogue than in the other kinds of antiglaucoma therapies.