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Journal of Ophthalmology
Volume 2015, Article ID 171690, 5 pages
Research Article

Effect of Glyceraldehyde Cross-Linking on a Rabbit Bullous Keratopathy Model

Hebei Provincial Eye Hospital, Hebei Provincial Ophthalmology Key Lab, Hebei Provincial Institute of Ophthalmology, Xingtai, Hebei 054001, China

Received 31 May 2015; Revised 14 July 2015; Accepted 26 July 2015

Academic Editor: Vito Romano

Copyright © 2015 Mengmeng Wang. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Background. To evaluate the effects of corneal glyceraldehyde CXL on the rabbit bullous keratopathy models established by descemetorhexis. Methods. Fifteen rabbits were randomly divided into five groups. Group A () is the control group. The right eyes of animals in Groups B,C, D, and E (, resp.) were suffered with descemetorhexis procedures. From the 8th day to the 14th day postoperatively, the right eyes in Groups C and D were instilled with hyperosmolar drops and glyceraldehyde drops, respectively; the right eyes in Group E were instilled with both hyperosmolar drops and glyceraldehyde drops. Central corneal thickness (CCT), corneal transparency score, and histopathological analysis were applied on the eyes in each group. Results. Compared with Group A, statistically significant increase in CCT and corneal transparency score was found in Groups B, C, D, and E at 7 d postoperatively () and in Groups C, D, and E at 14 d postoperatively (). Conclusion. Chemical CXL technique using glyceraldehyde improved the CCT and corneal transparency of the rabbit bullous keratopathy models. Topical instillation with glyceraldehyde and hyperosmolar solutions seems to be a good choice for the bullous keratopathy treatment.