Histological Characterization of the Dicer1 Mutant Zebrafish Retina

Figure 5

Ultrastructure of RPE cells and outer segment of photoreceptor of Dicer1 mutant zebrafish. (a) Part of Bruch’s membrane and RPE cells interdigitate with outer segments (OS) of photoreceptor. The RPE cells contained a large nucleus and melanin pigmented granules. Drusen were not present above the Bruch’s membrane. (b) Part of the Bruch’s membrane showing the normal fibrillar structure. Drusens were not present above the Bruch’s membrane. (c) Part of the outer segment (OS) and RPE containing large nucleus, lysosome, mitochondria, and melanosomes (melanin pigmented granules). (d) Part of the outer segment showing regular disc lamellae. B: Bruch’s membrane, GCL: ganglion cell layer, INL: inner nuclear layer, IPL: inner plexiform layer, L: lysosome, M: mitochondria, MP: melanosome (melanin pigmented granules), N: nucleus, ONL: outer nuclear layer, OS: outer segment, PL: photoreceptor layer, RPE: retinal pigmented epithelial cells.

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