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Journal of Ophthalmology
Volume 2015, Article ID 359747, 7 pages
http://dx.doi.org/10.1155/2015/359747
Clinical Study

Preservation of the Photoreceptor Inner/Outer Segment Junction in Dry Age-Related Macular Degeneration Treated by Rheohemapheresis

1Department of Ophthalmology, Lékařská Fakulta, Fakultní Nemocnice, Sokolská 581, 500 09 Hradec Králové, Czech Republic
2Fourth Department of Internal Medicine–Hematology, Lékařská Fakulta, Fakultní Nemocnice, Sokolská 581, 500 09 Hradec Králové, Czech Republic
3Department of Gerontology and Metabolic Care, Lékařská Fakulta, Fakultní Nemocnice, Sokolská 581, 500 09 Hradec Králové, Czech Republic
4Department of Radiology, Lékařská Fakulta, Fakultní Nemocnice, Sokolská 581, 500 09 Hradec Králové, Czech Republic

Received 27 March 2015; Revised 19 May 2015; Accepted 21 June 2015

Academic Editor: Bartosz Sikorski

Copyright © 2015 Eva Rencová et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Aim. To evaluate the long-term effect of rheohemapheresis (RHF) treatment of age-related macular degeneration (AMD) on photoreceptor IS/OS junction status. Methods. In our study, we followed 24 patients with dry AMD and drusenoid retinal pigment epithelium detachment (DPED) for a period of more than 2.5 years. Twelve patients (22 eyes) were treated by RHF and 12 controls (18 eyes) were randomized. The treated group underwent 8 RHF standardized procedures. We evaluated best-corrected visual acuity, IS/OS junction status (SD OCT), and macular function (multifocal electroretinography) at baseline and at 2.5-year follow-up. Results. RHF caused a decrease of whole-blood viscosity/plasma viscosity at about 15/12%. BCVA of treated patients increased insignificantly from median 74.0 letters (56.2 to 81.3 letters) to median 79.0 letters (57.3 to 83.4 letters), but it decreased significantly from 74.0 letters (25.2 to 82.6 letters) to 72.5 letters (23.4 to 83.1 letters) in the control group . The mfERG responses in the region of eccentricity between 1.8° and 7° were significantly higher in treated patients . Conclusions. RHF contributed to sparing of photoreceptor IS/OS junction integrity in the fovea, which is assumed to be a predictive factor for preservation of visual acuity.