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Type of component | Study design | Year | Patient number | Corneal disease | Clotting phase | Centrifugation/time | Dilution | Storage | Results | References |
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100% AS | Single-center prospective interventional study | 2013 | 181 | Corneal epithelial defects after ocular surgery | 2 h at RT | 3000 g/15 min | None | −20°C three months | It improves corneal healing. | [94] |
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50% AS | Single-center prospective study | 2014 | 28 | Acute and chronic eye pathologies | 24–48 h at 4°C | 4000 g/10 min | Sterile saline solution | −30°C six months −20°C three months | It stabilizes and improves signs and symptoms in eyes previously treated with conventional therapy. | [91] |
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20% AS, CBS | Double-blind prospective randomized controlled clinical study | 2011 | 33 | Ocular chemical burns of grades III, IV, and V | Not provided | 1800 g/10 min | Sterile balanced salt solution | −20.0°C until use | Umbilical cord serum therapy is more effective than AS eye drops or artificial tears in ocular surface restoration after acute chemical injuries. | [112] |
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20% AS versus AMT | Retrospective study | 2014 | 42 | Neurotrophic keratitis Corneal ulcers | 2 h | 3000 g/15 min | Sterile saline solution | Not provided | Amniotic membrane transplantation is more effective than AS in deep corneal ulcers with postherpes neurotrophic keratitis. | [105] |
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100% AS | Not provided | 2013 | 10 | PED | 2 h at RT | 3000 g/15 min | None | 4°C | Improvement in corneal healing. | [115] |
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100% AS | Descriptive prospective observational study | 2011 | 15 | Various ocular surface disorders | None | 10000 rpm/10 min | None | −20°C three months | Redness, burning, sharp pain, and tired eyes improved in 100% of the patients, whereas dryness and sandy/gritty sensation improved in 92% of the patients. | [69] |
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20% AS, 20% no AS | Prospective interventional study | 2010 | 165 | PED after PK | 30 min | 1500 rpm/5 min | Sterile saline solution | −4°C | AS improves healing in patients with potentially delayed epithelial heal. | [93] |
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20% AS | Prospective, double-blind randomized crossover study | 2014 | 40 | Severe DES | 2 h at RT | 2600 g/10 min | Sterile saline solution | −20°C | AS eye drops are more effective than conventional eye drops for improving tear film stability and subjective comfort in patients with severe DES. | [92] |
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100% AS versus normal saline/ artificial tears/ antibiotics AS | Randomized study | 2013 | 85 | DES/SS, DES/no SS, PED | 5 min at RT | 3000 g/5 min | None versus 50% saline or artificial tears or antibiotic | Not provided | AS was the most effective in decreasing symptoms, corneal epitheliopathy, and promoting fast closure of wound. | [88] |
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50% AS | Prospective cross-sectional study | 2014 | 34 | SS | 2 h at RT | 3000 g/15 min | Sodium hyaluronate | −70°C until use | AS might not be effective for the treatment of secondary SS because of elevated serum proinflammatory cytokine levels. | [101] |
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20% AS | Three-month prospective study | 2014 | 17 | Severe DES | Not provided | 3000 g/15 min | Isotonic buffered saline solution | −20°C four months 4–8°C one week | The positive effect of AS decreased with time but still persisted up to three months after the end of therapy. | [102] |
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20% AS | Double-blind prospective randomized controlled clinical study |
2011 | 32 | Acute chemical burns | Not provided | 180 g/10 min | Sterile balanced solution | −20°C until use | Umbilical cord serum was more effective than AS and artificial tears in ocular surface restitution. | [112] |
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20% AS versus PRP | Retrospective review | 2012 | 28 | DES | Not provided | 3000 g/15 min 200 g/11 min | Sterile saline solution | −20°C until use | The concentrations of GFs in the PRP and AS were not statistically different. PRP could be an effective, novel treatment option for chronic ocular surface disease. | [70] |
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20% AS versus conventional artificial tears treatment | Double masked randomized crossover clinical trial | 2012 | 12 | Severe DES | 2 h at RT | 3500 rpm/5 min at 4°C | Sterile saline solution | −20°C | AS achieves better symptom improvement compared to artificial tears in a short-term treatment. | [79] |
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