The Role of the Endothelin System in the Vascular Dysregulation Involved in Retinitis Pigmentosa

Table 1

The local and systemic increase of ET-1 and the vascular dysregulation syndrome in RP.

Drop in ocular blood flow	(i) Altered vessel caliber
	(ii) Impaired vascular tone
	(iii) Neurovascular coupling
Drop in O2 retinal supply	(i) Vasospasm
	(ii) Ischemia
	(iii) Hypoxia
	(iv) Biochemical and metabolic alterations of retinochoroidal endothelial cells
Degeneration of PRs	(i) Chronic oxidative stress
	(ii) Subclinical inflammation

ET-1: endothelin-1; RP: retinitis pigmentosa; PRs: photoreceptors.