The Role of RPGR and Its Interacting Proteins in Ciliopathies

Figure 1

The photoreceptor primary cilia. The distinct compartments of both rod and cone cells (left side). Protein trafficking in photoreceptor connecting cilium through intraflagellar transport (IFT) is carried out by motor proteins, kinesin and dynein (right side). CEP290, centrosomal protein 290 kDa; NPHP4, nephronophthisis 4; RPGR, retinitis pigmentosa GTPase regulator; RPGRIP1, RPGR interacting protein 1; RPGRIP1L, RPGR interacting protein 1-like (right side).