The Effect of Hormone Replacement Therapy on Dry Eye Syndrome Evaluated with Schirmer Test and Break-Up Time

Table 3

Schirmer test results of the included studies.

Study	Schirmer test under anesthesia	Schirmer test result (mm) before beginning the study		Schirmer test result (mm) after treatment		Calculated difference (mm) between values before beginning the study and after treatment		HRT effect
		HRT group	Control group	HRT group	Control group	HRT group	Control group
Erdem et al., 2007 [14]	Yes	3.9 ± 1.1	4.1 ± 0.8	3.2 ± 0.9	4.1 ± 0.9	−0.7 ± 1.01	0 ± 0.85	Negative
Affinito et al., 2003a [7]	Yes	3.3 ± 1.5	3.2 ± 1.4	5.1 ± 1.3	3.4 ± 1.2	1.8 ± 1.41	0.2 ± 1.31	Positive
Guaschino et al., 2003 [6]	No	19.6 ± 8.1	17.8 ± 7.8	25.7 ± 7.9	17.4 ± 8.8	6.1 ± 8	−0.4 ± 8.35	Positive
Affinito et al., 2003b [7]	No	13.4 ± 2.1	13.5 ± 2.7	17.8 ± 2.4	14.0 ± 2.8	4.4 ± 2.26	0.5 ± 2.75	Positive
Taner et al., 2004 [15]	Not mentioned, but considered no	11.7 ± 0.9	12.8 ± 1.0	11.68 ± 1.0	12.7 ± 1.0	−0.02 ± 0.95	−0.1 ± 1	Negative
Scuderi et al., 2012a [13]	Not mentioned, but considered no	1.45 ± 1.32	1.36 ± 1.31	5.63 ± 3.16	1.45 ± 1.09	4.18 ± 2.75	0.09 ± 1.22	Positive
Scuderi et al., 2012b [13]	Not mentioned, but considered no	1.09 ± 1.18	2.00 ± 1.22	6.36 ± 2.84	1.18 ± 1.04	5.27 ± 2.47	−0.82 ± 1.14	Positive

HRT: hormone replacement therapy. Affinito 2003a and Affinito 2003b are the same study. The data for Schirmer tests with and without anesthetics were extracted and marked as Affinito 2003a and Affinito 2003b, respectively. Scuderi 2012a and Scuderi 2012b are the same study. The data for Schirmer tests from original grouping and reversed grouping are extracted and marked as Scuderi 2012a and Scuderi 2012b, respectively.