The Effect of Hormone Replacement Therapy on Dry Eye Syndrome Evaluated with Schirmer Test and Break-Up Time

Table 4

Break-up time results of the included studies.

Study	Break-up time (s) before beginning of the study		Break-up time (s) after treatment		Calculated difference (s) between values after treatment and before beginning of the study		HRT effect
	HRT group	Control group	HRT group	Control group	HRT group	Control group
Erdem et al., 2007 [14]	4.1 ± 0.9	4.2 ± 0.7	4.0 ± 0.5	4.2 ± 0.9	−0.1 ± 0.78	0.0 ± 0.82	Negative
Taner et al., 2004 [15]	12.0 ± 1.0	11.9 ± 0.9	12.2 ± 0.8	11.8 ± 1.0	0.2 ± 0.92	−0.1 ± 0.95	Negative
Scuderi et al., 2012a [13]	0.72 ± 0.761	0.72 ± 0.761	7.54 ± 2.09	0.90 ± 0.80	6.82 ± 1.83	0.18 ± 0.78	Positive
Scuderi et al., 2012b [13]	1.81 ± 1.35	1.72 ± 0.80	6.54 ± 2.91	0.60 ± 0.78	4.73 ± 2.52	−1.12 ± 0.79	Positive

HRT: hormone replacement therapy. Scuderi 2012a and Scuderi 2012b are the same study. The data of break-up time from original grouping and reversed grouping are extracted and marked as Scuderi 2012a and Scuderi 2012b, respectively.