The Measurement of Intraocular Biomarkers in Various Stages of Proliferative Diabetic Retinopathy Using Multiplex xMAP Technology

Table 1

Descriptive statistics. Median values and 5th and 95th percentile values in pg/mL for all markers and groups are shown. Proliferative diabetic retinopathy (PDR) patients were divided into groups. Group 1: PDR patients with no need for repeated surgical intervention; group 2: PDR patients with repeated vitreous bleeding, which is a less serious complication of PDR; group 3: PDR patients with refractory neovascular glaucoma, which is a serious complication of PDR; group 0: control group.

	Groups
	0		1		2		3
	Median	5–95 P	Median	5–95 P	Median	5–95 P	Median	5–95 P
BDNF	12.00	12.00–59.67	12.00	12.00–49.37	12.00	12.00–103.23	30.00	12.00–81.43
CNTF	122.00	122.00–2667.92	393.19	122.00–1787.45	276.19	122.00–573.63	388.29	197.96–578.61
EGF	24.88	13.893–115.99	36.22	14.02–133.31	96.47	4.23–120.42	37.48	3.95–114.20
IL-6	3.20	3.200–196.312	37.19	3.992–4577.38	25.22	3.37–299.13	384.74	22.63–9982.69
IL-8	3.20	3.20–15.49	25.28	13.21–184.62	27.96	13.84–53.67	33.76	20.04–96.37
IP-10	105.92	12.93–307.68	460.68	159.49–2237.28	365.35	150.90–758.61	874.06	463.94–1698.36
MCP-1	962.59	3.20–2931.63	2772.21	353.18–3249.45	2336.77	2020.39–2653.15	661.23	3.20–2881.94
PDGFAA	111.26	5.85–212.85	227.96	104.57–756.34	208.36	151.58–344.62	192.66	79.91–316.61
TGF-1	49.00	49.00-49.00	49.00	49.00–220.41	49.00	49.00–84.71	414.40	119.85–955.58
VEGF	69.85	16.00–200.63	211.62	48.10–1990.98	187.96	4.28–523.25	352.82	132.84–7052.89

BDNF: brain-derived neurotrophic factor; CNTF: ciliary neurotrophic factor; EGF: epidermal growth factor; IL: interleukin; IP-10: -interferon inducible protein 10; MCP-1: monocyte chemoattractant protein 1; PDGF AA: platelet-derived growth factor AA; TGF-1: transforming growth factor beta 1; VEGF: vascular endothelial growth factor.
P: percentile.