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Journal of Ophthalmology
Volume 2015, Article ID 437271, 4 pages
Research Article

Decreased Perifoveal Sensitivity Detected by Microperimetry in Patients Using Hydroxychloroquine and without Visual Field and Fundoscopic Anomalies

1Clínica Optométrica, Fundació Lluis Alcanyis, Universitat de Valencia, Calle de la Guardia Civil 22, 46020 Valencia, Spain
2Oftalmar, Hospital Internacional Medimar, Edificio de Especialidades, 03016 Alicante, Spain
3Departamento de Óptica, Anatomía y Farmacología, Universidad de Alicante, Carretera de San Vicente del Raspeig s/n, 03690 Alicante, Spain

Received 19 January 2015; Accepted 6 March 2015

Academic Editor: Stephen Charn Beng Teoh

Copyright © 2015 A. Molina-Martín et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Purpose. To evaluate the usefulness of microperimetry in the early detection of the ocular anomalies associated with the use of hydroxychloroquine. Methods. Prospective comparative case series study comprising 14 healthy eyes of 7 patients (group A) and 14 eyes of 7 patients under treatment with hydroxychloroquine for the treatment of rheumatologic diseases and without fundoscopic or perimetric anomalies (group B). A comprehensive ophthalmological examination including microperimetry (MP) and spectral-domain optical coherence tomography was performed in both groups. Results. No significant differences were found in mean MP foveal sensitivity between groups . However, mean MP overall sensitivity was significantly higher in group A ( dB versus group B,  dB; ). Significantly higher sensitivity values were obtained in group A in comparison to group B for the three eccentric loci evaluated . Conclusion. Microperimetry seems to be a useful tool for the early detection of retinal damage in patients treated with hydroxychloroquine.