Association between Ophthalmic Timolol and Hospitalisation for Bradycardia

Table 2

Self-controlled case series results for patients with a hospitalisation for bradycardia and at least one dispensing of timolol.

Risk periods	hospitalisations	Person-years	Adjusted rate^a per 10 years (95% CI)	IRR^a (95% CI)
Unexposed	161	1112	1.42 (1.17–1.71)	1.00 (1.00-1.00)
Before 1–30 days	2	22	0.82 (0.20–3.30)	0.58 (0.14–2.35)
After 1–30 days	25	127	1.98 (1.30–3.03)	1.40 (0.87–2.26)
After 31–180 days	58	234	2.73 (1.99–3.75)	1.93 (1.30–2.87)
After 180 days	17	121	1.72 (0.96–3.07)	1.21 (0.64–2.31)
Washout	4	63	0.60 (0.22–1.63)	0.42 (0.15–1.17)

CI: confidence interval; IRR: incidence rate ratio.
^aAdjusted for age at hospitalisation and calendar year.