Epigenetic Regulation of Werner Syndrome Gene in Age-Related Cataract
Methylation status at region 3 in WRN promoter in anterior lens capsules and cortex of control and ARC. (a) The positions of CpG islands within WRN promoter. In the following panels, each row of circles represents a single clone. Open and close circles represent unmethylated and methylated CpG sites, respectively. (b) Methylation status of region 3 in WRN promoter in anterior lens capsules of control () and ARC-C (), ARC-N (), and ARC-P (). The ARC group displayed hypermethylation compared to the control group. . (c) Methylation status of region 3 in WRN promoter in lens cortex of control and ARC lens. There were no significant statistical differences between the ARC group and the control group. .