Epigenetic Regulation of Werner Syndrome Gene in Age-Related Cataract
Histone modifications of the WRN promoter in anterior lens capsules of control and ARC. In anterior lens capsules, compared with the control group (), ChIP analysis revealed that acetylated H3 levels were lower in ARC-C (), ARC-N (), and ARC-P (). At the same time, methylated H3-K9 was increased. .