Table of Contents Author Guidelines Submit a Manuscript
Journal of Ophthalmology
Volume 2015, Article ID 584854, 9 pages
http://dx.doi.org/10.1155/2015/584854
Research Article

Identification of Iron Homeostasis Genes Dysregulation Potentially Involved in Retinopathy of Prematurity Pathogenicity by Microarray Analysis

1Department of Neonatology, Guangdong Women and Children’s Hospital, Guangzhou 511400, China
2Jinan University, Guangzhou 511000, China
3Medical Genetics Center, Guangdong Women and Children’s Hospital, Guangzhou 511400, China
4Translational Medicine Center, Guangdong Women and Children’s Hospital, Guangzhou 511400, China

Received 14 July 2015; Revised 28 September 2015; Accepted 29 September 2015

Academic Editor: Terri L. Young

Copyright © 2015 Xian-qiong Luo et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. B. A. Darlow, J. L. Hutchinson, D. J. Henderson-Smart, D. A. Donoghue, J. M. Simpson, and N. J. Evans, “Prenatal risk factors for severe retinopathy of prematurity among very preterm infants of the Australian and New Zealand Neonatal Network,” Pediatrics, vol. 115, no. 4, pp. 990–996, 2005. View at Publisher · View at Google Scholar · View at Scopus
  2. S. M. Husain, A. K. Sinha, C. Bunce et al., “Relationships between maternal ethnicity, gestational age, birth weight, weight gain, and severe retinopathy of prematurity,” The Journal of Pediatrics, vol. 163, no. 1, pp. 67–72, 2013. View at Publisher · View at Google Scholar · View at Scopus
  3. J. J. Pietrzyk, P. Kwinta, M. Bik-Multanowski et al., “New insight into the pathogenesis of retinopathy of prematurity: assessment of whole-genome expression,” Pediatric Research, vol. 73, no. 4, pp. 476–483, 2013. View at Publisher · View at Google Scholar · View at Scopus
  4. X. Reynaud and C. K. Dorey, “Extraretinal neovascularization induced by hypoxic episodes in the neonatal rat,” Investigative Ophthalmology & Visual Science, vol. 35, no. 8, pp. 3169–3177, 1994. View at Google Scholar · View at Scopus
  5. Y. Yuan, G. Hilliard, T. Ferguson, and D. E. Millhorn, “Cobalt inhibits the interaction between hypoxia-inducible factor-α and von Hippel-Lindau protein by direct binding to hypoxia-inducible factor-α,” Journal of Biological Chemistry, vol. 278, no. 18, pp. 15911–15916, 2003. View at Publisher · View at Google Scholar · View at Scopus
  6. Z. Xiaozhuang, L. Xianqiong, J. Jingbo, H. Shuiqing, Y. Jie, and C. Yunbin, “Isolation and characterization of fetus human retinal microvascular endothelial cells,” Ophthalmic Research, vol. 44, no. 2, pp. 125–130, 2009. View at Publisher · View at Google Scholar · View at Scopus
  7. X. Su, C. M. Sorenson, and N. Sheibani, “Isolation and characterization of murine retinal endothelial cells,” Molecular Vision, vol. 9, pp. 171–178, 2003. View at Google Scholar · View at Scopus
  8. T. Uchida, F. Rossignol, M. A. Matthay et al., “Prolonged hypoxia differentially regulates hypoxia-inducible factor (HIF)-1α and HIF-2α expression in lung epithelial cells: implication of natural antisense HIF-1α,” The Journal of Biological Chemistry, vol. 279, no. 15, pp. 14871–14878, 2004. View at Publisher · View at Google Scholar
  9. G. L. Wang, B.-H. Jiang, E. A. Rue, and G. L. Semenza, “Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension,” Proceedings of the National Academy of Sciences of the United States of America, vol. 92, no. 12, pp. 5510–5514, 1995. View at Publisher · View at Google Scholar · View at Scopus
  10. M. G. Yefimova, J.-C. Jeanny, X. Guillonneau et al., “Iron, ferritin, transferrin, and transferrin receptor in the adult rat retina,” Investigative Ophthalmology and Visual Science, vol. 41, no. 8, pp. 2343–2351, 2000. View at Google Scholar · View at Scopus
  11. X. He, P. Hahn, J. Iacovelli et al., “Iron homeostasis and toxicity in retinal degeneration,” Progress in Retinal and Eye Research, vol. 26, no. 6, pp. 649–673, 2007. View at Publisher · View at Google Scholar · View at Scopus
  12. M. Shohat, S. H. Reisner, R. Krikler, I. Nissenkorn, Y. Yassur, and I. Ben-Sira, “Retinopathy of prematurity: incidence and risk factors,” Pediatrics, vol. 72, no. 2, pp. 159–163, 1983. View at Google Scholar · View at Scopus
  13. R. W. Cooke, D. Clark, M. Hickey-Dwyer, and A. M. Weindling, “The apparent role of blood transfusions in the development of retinopathy of prematurity,” European Journal of Pediatrics, vol. 152, no. 10, pp. 833–836, 1993. View at Google Scholar
  14. C. Dani, M. F. Reali, G. Bertini, E. Martelli, M. Pezzati, and F. F. Rubaltelli, “The role of blood transfusions and iron intake on retinopathy of prematurity,” Early Human Development, vol. 62, no. 1, pp. 57–63, 2001. View at Publisher · View at Google Scholar · View at Scopus
  15. A. Van Sorge, F. Kerkhoff, F. J. Halbertsma, and N. Schalij-Delfos, “Severe retinopathy of prematurity in twin-twin transfusion syndrome after multiple blood transfusions,” Acta Ophthalmologica, vol. 92, no. 2, pp. e167–e168, 2014. View at Publisher · View at Google Scholar · View at Scopus
  16. L. Hesse, W. Eberl, M. Schlaud, and C. F. Poets, “Blood transfusion. Iron load and retinopathy of prematurity,” European Journal of Pediatrics, vol. 156, no. 6, pp. 465–470, 1997. View at Publisher · View at Google Scholar · View at Scopus
  17. K. Hirano, T. Morinobu, H. Kim et al., “Blood transfusion increases radical promoting non-transferrin bound iron in preterm infants,” Archives of Disease in Childhood: Fetal and Neonatal Edition, vol. 84, no. 3, pp. F188–F193, 2001. View at Publisher · View at Google Scholar · View at Scopus
  18. P. A. Dennery, D. R. Spitz, G. Yang et al., “Oxygen toxicity and iron accumulation in the lungs of mice lacking heme oxygenase-2,” The Journal of Clinical Investigation, vol. 101, no. 5, pp. 1001–1011, 1998. View at Publisher · View at Google Scholar · View at Scopus
  19. D. M. Suttner and P. A. Dennery, “Reversal of HO-1 related cytoprotection with increased expression is due to reactive iron,” The FASEB Journal, vol. 13, no. 13, pp. 1800–1809, 1999. View at Google Scholar · View at Scopus
  20. P. A. Dennery, H. E. Wong, K. J. Sridhar, P. A. Rodgers, J. E. Sim, and D. R. Spitz, “Differences in basal and hyperoxia-associated HO expression in oxidant-resistant hamster fibroblasts,” American Journal of Physiology: Lung Cellular and Molecular Physiology, vol. 271, no. 4, pp. L672–L679, 1996. View at Google Scholar · View at Scopus
  21. J. C. Duvigneau, C. Piskernik, S. Haindl et al., “A novel endotoxin-induced pathway: upregulation of heme oxygenase 1, accumulation of free iron, and free iron-mediated mitochondrial dysfunction,” Laboratory Investigation, vol. 88, no. 1, pp. 70–77, 2008. View at Publisher · View at Google Scholar · View at Scopus
  22. O. N. Ursu, M. Sauter, N. Ettischer, R. Kandolf, and K. Klingel, “Heme oxygenase-1 mediates oxidative stress and apoptosis in coxsackievirus B3-induced myocarditis,” Cellular Physiology and Biochemistry, vol. 33, no. 1, pp. 52–66, 2014. View at Publisher · View at Google Scholar · View at Scopus
  23. W. Chen, D. M. Hunt, H. Lu, and R. C. Hunt, “Expression of antioxidant protective proteins in the rat retina during prenatal and postnatal development,” Investigative Ophthalmology and Visual Science, vol. 40, no. 3, pp. 744–751, 1999. View at Google Scholar · View at Scopus
  24. G. Nie, A. D. Sheftel, S. F. Kim, and P. Ponka, “Overexpression of mitochondrial ferritin causes cytosolic iron depletion and changes cellular iron homeostasis,” Blood, vol. 105, no. 5, pp. 2161–2167, 2005. View at Publisher · View at Google Scholar · View at Scopus
  25. Z. Lu, G. Nie, Y. Li et al., “Overexpression of mitochondrial ferritin sensitizes cells to oxidative stress via an iron-mediated mechanism,” Antioxidants and Redox Signaling, vol. 11, no. 8, pp. 1791–1803, 2009. View at Publisher · View at Google Scholar · View at Scopus
  26. T. P. Ryan, R. F. Krzesicki, D. P. Blakeman et al., “Pulmonary ferritin: differential effects of hyperoxic lung injury on subunit mRNA levels,” Free Radical Biology and Medicine, vol. 22, no. 5, pp. 901–908, 1997. View at Publisher · View at Google Scholar · View at Scopus
  27. D. W. Reif, “Ferritin as a source of iron for oxidative damage,” Free Radical Biology and Medicine, vol. 12, no. 5, pp. 417–427, 1992. View at Publisher · View at Google Scholar · View at Scopus
  28. A. E. Deans, Y. Z. Wadghiri, L. M. Bernas, X. Yu, B. K. Rutt, and D. H. Turnbull, “Cellular MRI contrast via coexpression of transferrin receptor and ferritin,” Magnetic Resonance in Medicine, vol. 56, no. 1, pp. 51–59, 2006. View at Publisher · View at Google Scholar · View at Scopus
  29. T. A. Rouault, “The role of iron regulatory proteins in mammalian iron homeostasis and disease,” Nature Chemical Biology, vol. 2, no. 8, pp. 406–414, 2006. View at Publisher · View at Google Scholar · View at Scopus
  30. M. C. Ghosh, W.-H. Tong, D. Zhang et al., “Tempol-mediated activation of latent iron regulatory protein activity prevents symptoms of neurodegenerative disease in IRP2 knockout mice,” Proceedings of the National Academy of Sciences of the United States of America, vol. 105, no. 33, pp. 12028–12033, 2008. View at Publisher · View at Google Scholar · View at Scopus
  31. P. Aisen, “Transferrin receptor 1,” International Journal of Biochemistry and Cell Biology, vol. 36, no. 11, pp. 2137–2143, 2004. View at Publisher · View at Google Scholar · View at Scopus
  32. M. W. Hentze, M. U. Muckenthaler, and N. C. Andrews, “Balancing acts: molecular control of mammalian iron metabolism,” Cell, vol. 117, no. 3, pp. 285–297, 2004. View at Publisher · View at Google Scholar · View at Scopus
  33. G. L. Semenza, “HIF-1, O2, and the 3 PHDs. How animal cells signal hypoxia to the nucleus,” Cell, vol. 107, no. 1, pp. 1–3, 2001. View at Publisher · View at Google Scholar · View at Scopus
  34. C. Peyssonnaux, V. Nizet, and R. S. Johnson, “Role of the hypoxia inducible factors in iron metabolism,” Cell Cycle, vol. 7, no. 1, pp. 28–32, 2008. View at Publisher · View at Google Scholar · View at Scopus
  35. C. N. Lok and P. Ponka, “Identification of a hypoxia response element in the transferrin receptor gene,” The Journal of Biological Chemistry, vol. 274, no. 34, pp. 24147–24152, 1999. View at Publisher · View at Google Scholar · View at Scopus
  36. L. Tacchini, L. Bianchi, A. Bernelli-Zazzera, and G. Cairo, “Transferrin receptor induction by hypoxia. HIF-1-mediated transcriptional activation and cell-specific post-transcriptional regulation,” The Journal of Biological Chemistry, vol. 274, no. 34, pp. 24142–24146, 1999. View at Publisher · View at Google Scholar · View at Scopus
  37. P. Dore-Duffy, R. Balabanov, T. Beaumont, M. A. Hritz, S. I. Harik, and J. C. Lamanna, “Endothelial activation following prolonged hypobaric hypoxia,” Microvascular Research, vol. 57, no. 2, pp. 75–85, 1999. View at Publisher · View at Google Scholar · View at Scopus
  38. N. Zhao, A.-S. Zhang, and C. A. Enns, “Iron regulation by hepcidin,” The Journal of Clinical Investigation, vol. 123, no. 6, pp. 2337–2343, 2013. View at Publisher · View at Google Scholar · View at Scopus
  39. D. F. Wallace, L. Summerville, P. E. Lusby, and V. N. Subramaniam, “First phenotypic description of transferrin receptor 2 knockout mouse, and the role of hepcidin,” Gut, vol. 54, no. 7, pp. 980–986, 2005. View at Publisher · View at Google Scholar · View at Scopus
  40. P. M. Martin, J. P. Gnana-Prakasam, P. Roon, R. G. Smith, S. B. Smith, and V. Ganapathy, “Expression and polarized localization of the hemochromatosis gene product HFE in retinal pigment epithelium,” Investigative Ophthalmology and Visual Science, vol. 47, no. 10, pp. 4238–4244, 2006. View at Publisher · View at Google Scholar · View at Scopus
  41. S. Kotamraju, Y. Tampo, A. Keszler et al., “Nitric oxide inhibits H2O2-induced transferrin receptor-dependent apoptosis in endothelial cells: role of ubiquitin-proteasome pathway,” Proceedings of the National Academy of Sciences of the United States of America, vol. 100, no. 19, pp. 10653–10658, 2003. View at Publisher · View at Google Scholar · View at Scopus
  42. F. Cervellati, C. Cervellati, A. Romani et al., “Hypoxia induces cell damage via oxidative stress in retinal epithelial cells,” Free Radical Research, vol. 48, no. 3, pp. 303–312, 2014. View at Publisher · View at Google Scholar · View at Scopus