Blockade of Vascular Endothelial Growth Factor Receptor 1 Prevents Inflammation and Vascular Leakage in Diabetic Retinopathy
Inhibition of diabetes-caused albumin leakage by VEGFR1 blockade. ((a)–(i)) The representative immunofluorescence (IF) images were taken from the nondiabetic control mice ((a)–(c)) and the STZ-induced diabetic mice that were treated with rat IgG ((d)–(f)) or MF1 ((g)–(i)). The diabetic duration was 3 months (or 13 weeks) and the total time of rat IgG or MF1 treatment was 39 (3 times/week). Scale bar: 100 μm. (j) Quantification showed the size ratio of albumin (+) areas versus CD31 (+) blood vessel areas in the three groups. The results were averaged from 4 mice .