Table 1: Clinical characteristics of male twins affected by Leber congenital amaurosis.

Family
ID
Patient Age at onset (months) Age at first visit (months) Current age (months)Follow-up duration (months) Gender Origin Inheritance pattern Primary symptom Night blindness Photophobia Nystagmus Hyperopia Refraction (diopters)ERG Fundus abnormalities
Right eyeLeft eyeRight eyeLeft eye

LCA1HTwin 1 (II-1)3112918MaleHamamatsu, JapanarNo ocular pursuit++++3.00+3.25NRNRMild RPE changes around disc.
Slight retinal vessels narrowing.
Twin 2 (II-2)3112918MaleHamamatsu, JapanarNo ocular pursuit++++6.00+5.00NRNRMild RPE changes around disc.
Slight retinal vessels narrowing.

Age at onset was based on medical history; age at first visit was based on medical records.
All clinical data were obtained from recent examinations.
ar: autosomal recessive; ERG: electroretinogram; NR: nonrecordable; RPE: retinal pigment epithelium.