Evaluation of Four Genetic Variants in Han Chinese Subjects with High Myopia

Table 2

Association between HM and four SNPs (rs2969180, rs1652333, rs9307551, and rs7837791) in a Han Chinese population.

SNP	Chromosome	Position	Gene	Minor allele	MAF		_HWE		Allelic	Corrected	OR (95% CI)
					Patient	Control	Patient	Control
rs2969180	17	11407900	SHISA6	G	0.472	0.483	0.208	0.722	0.581	1	1.04 (0.90–1.22)
rs1652333	1	203858855	CD55	T	0.452	0.420	0.615	0.707	0.936	1	1.00 (0.85–1.16)
rs9307551	4	80530670	LOC100506035	A	0.505	0.445	0.302	0.580	2.46 × 10^−4	9.84 × 10^−4	1.33 (1.14–1.54)
rs7837791	8	60179085	TOX	T	0.478	0.473	0.888	0.064	0.605	1	1.04 (0.90–1.21)

Allelic value has been adjusted by age and sex.
ORs (95% CI) have been adjusted by age and sex and were determined by the test, patients versus controls.
^&Corrected = allelic   ×  4 (the number of genotyped SNPs).
SNP: single nucleotide polymorphism; MAF: minor allele frequency; HWE: Hardy-Weinberg equilibrium; OR: odds ratio.