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Journal of Ophthalmology
Volume 2015, Article ID 731461, 6 pages
Clinical Study

Aqueous Levels of Pigment Epithelium-Derived Factor and Macular Choroidal Thickness in High Myopia

1Clinical College of Ophthalmology, Tianjin Medical University, No. 4, Gansu Road, Tianjin 300020, China
2Department of Ophthalmology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan 250000, China

Received 14 July 2014; Revised 1 October 2014; Accepted 21 October 2014

Academic Editor: Ricardo Giordano

Copyright © 2015 Wei Chen et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Purpose. To investigate the correlation between aqueous and serum levels of pigment epithelium-derived factor (PEDF) and macular choroidal thickness in high myopia patients, both with and without choroidal neovascularization (CNV). Methods. Serum and aqueous levels of PEDF were measured by enzyme-linked immunosorbent assay in 36 high myopia patients (36 eyes) with no CNV (non-CNV group), 14 high myopia patients (14 eyes) with CNV (CNV group), and 42 nonmyopia patients (42 eyes) (control group). Macular choroidal thickness was measured by enhanced-depth imaging optical coherence tomography. Results. Aqueous levels of PEDF were significantly higher in CNV group compared with non-CNV () and control () groups. Macular choroidal thicknesses were significantly decreased in the non-CNV and CNV groups compared with the control () group. A statistically significant difference () was found between the CNV and non-CNV groups. There was a positive correlation between aqueous PEDF and macular choroidal thickness in the non-CNV group (), but no correlation with the CNV group. No correlation between serum PEDF and macular choroidal thickness was detected in the three groups. Conclusion. Variations in aqueous PEDF levels coincide with changes in macular choroidal thickness in high myopia patients with no CNV, while no such relationship exists in high myopia patients with CNV.