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Journal of Ophthalmology
Volume 2015, Article ID 793026, 6 pages
Clinical Study

Systemic Corticosteroids Therapy in the Management of Acute Zonal Occult Outer Retinopathy

1Department of Ophthalmology, Changhua Christian Hospital, Changhua City 500, Taiwan
2School of Medicine, Chung Shan Medical University, Taichung 402, Taiwan
3School of Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan
4Department of Ophthalmology, National Taiwan University Hospital, Taipei 100, Taiwan
5School of Medicine, National Taiwan University, Taipei 10617, Taiwan

Received 5 October 2014; Revised 24 November 2014; Accepted 23 December 2014

Academic Editor: Christoph Tappeiner

Copyright © 2015 San-Ni Chen et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Purpose. To report the efficacy of systemic steroid in treating acute zonal occult outer retinopathy (AZOOR). Methods. Retrospective study of 9 consecutive patients of AZOOR, who received systemic steroid therapy in Changhua Christian Hospital from 2005 to 2013, is presented. The duration of therapy was at least 3 months. Patients were evaluated with best corrected visual acuity (BCVA), optical coherence tomography (OCT), fluorescein angiography (FA), indocyanine green angiography (ICG), visual field test, and electroretinography (ERG). Results. At the initial visit, visual field defect was noted in all patients and impaired visual acuity was noted in 4 eyes. OCT examination revealed disrupted ellipsoid zone at the macular area in 8 eyes and outer nuclear layer (ONL) loss in 1 eye. At the end of follow-up, all patients had improvement of visual field. The 4 eyes with initial impaired visual acuity had BCVA recovering to 20/20. Follow-up OCT showed partial or complete recovery of the ellipsoid zone at the macular area in the 8 eyes with initial disrupted ellipsoid zone and stable condition in the eye with ONL loss. The mean follow-up duration was months. Conclusion. Visual improvement was achieved in most cases of recent onset AZOOR after systemic steroid treatment.