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Journal of Ophthalmology
Volume 2015, Article ID 795357, 4 pages
Clinical Study

Micro-Bypass Implantation for Primary Open-Angle Glaucoma Combined with Phacoemulsification: 4-Year Follow-Up

Ophthalmic Clinic, Department of Surgical Sciences, University of Turin, 10122 Turin, Italy

Received 2 September 2015; Accepted 7 October 2015

Academic Editor: Colin Clement

Copyright © 2015 Antonio Maria Fea et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Purpose. To report the long-term follow-up results in patients with cataract and primary open-angle glaucoma (POAG) randomly assigned to cataract surgery combined with micro-bypass stent implantation or phacoemulsification alone. Methods. 36 subjects with cataract and POAG were randomized in a 1 : 2 ratio to either iStent implantation and cataract surgery (combined group) or cataract surgery alone (control group). 24 subjects agreed to be evaluated again 48 months after surgery. Patients returned one month later for unmedicated washout assessment. Results. At the long-term follow-up visit we reported a mean IOP of 15,9 ± 2,3 mmHg in the iStent group and 17 ± 2,5 mmHg in the control group (). After washout, a 14,2% between group difference in favour of the combined group was statistically significant () for mean IOP reduction. A significant reduction in the mean number of medications was observed in both groups compared to baseline values ( in the combined group and in the control group). Conclusion. Patients in the combined group maintained low IOP levels after long-term follow-up. Cataract surgery alone showed a loss of efficacy in controlling IOP over time. Both treatments reduced the number of ocular hypotensive medications prescribed. This trial is registered with: NCT00847158.