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Journal of Ophthalmology
Volume 2015 (2015), Article ID 832784, 6 pages
Research Article

Evaluation of Retinal Nerve Fiber Layer and Ganglion Cell Complex in Patients with Optic Neuritis or Neuromyelitis Optica Spectrum Disorders Using Optical Coherence Tomography in a Chinese Cohort

1Department of Ophthalmology, Eye, Ear, Nose, and Throat Hospital, Fudan University, Shanghai 200031, China
2Department of Neurology, Huashan Hospital, Fudan University, Shanghai 200040, China

Received 20 June 2015; Revised 28 September 2015; Accepted 1 October 2015

Academic Editor: Jun Zhang

Copyright © 2015 Guohong Tian et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


We evaluate a cohort of optic neuritis and neuromyelitis optica (NMO) spectrum disorders patients in a territory hospital in China. The peripapillary retinal nerve fiber layer (RNFL) and macular ganglion cell complex (GCC) were measured using spectral-domain OCT after 6 months of acute onset. The results showed that both the peripapillary RNFL and macular GCC were significantly thinner in all optic neuritis subtypes compared to controls. In addition, the recurrent optic neuritis and NMO groups showed more severe damage on the RNFL and GCC pattern.