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Journal of Ophthalmology
Volume 2015 (2015), Article ID 865083, 7 pages
http://dx.doi.org/10.1155/2015/865083
Review Article

Effects of Vitreomacular Adhesion on Age-Related Macular Degeneration

Department of Ophthalmology, Institute of Vision Research, Yonsei University College of Medicine, Seoul 120-752, Republic of Korea

Received 23 February 2015; Accepted 7 June 2015

Academic Editor: John Byron Christoforidis

Copyright © 2015 Eui Chun Kang and Hyoung Jun Koh. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. R. Klein, T. Peto, A. Bird, and M. R. Vannewkirk, “The epidemiology of age-related macular degeneration,” American Journal of Ophthalmology, vol. 137, no. 3, pp. 486–495, 2004. View at Publisher · View at Google Scholar · View at Scopus
  2. W. L. Wong, X. Su, X. Li et al., “Global prevalence of age-related macular degeneration and disease burden projection for 2020 and 2040: a systematic review and meta-analysis,” The Lancet Global Health, vol. 2, no. 2, pp. e106–e116, 2014. View at Publisher · View at Google Scholar · View at Scopus
  3. L. K. Cheung and A. Eaton, “Age-related macular degeneration,” Pharmacotherapy, vol. 33, no. 8, pp. 838–855, 2013. View at Publisher · View at Google Scholar · View at Scopus
  4. J. S. Penn, A. Madan, R. B. Caldwell, M. Bartoli, R. W. Caldwell, and M. E. Hartnett, “Vascular endothelial growth factor in eye disease,” Progress in Retinal and Eye Research, vol. 27, no. 4, pp. 331–371, 2008. View at Publisher · View at Google Scholar · View at Scopus
  5. S. Velilla, J. J. García-Medina, A. García-Layana et al., “Smoking and age-related macular degeneration: review and update,” Journal of Ophthalmology, vol. 2013, Article ID 895147, 11 pages, 2013. View at Publisher · View at Google Scholar · View at Scopus
  6. I. Krebs, W. Brannath, C. Glittenberg, F. Zeiler, J. Sebag, and S. Binder, “Posterior vitreomacular adhesion: a potential risk factor for exudative age-related macular degeneration?” American Journal of Ophthalmology, vol. 144, no. 5, pp. 741–746, 2007. View at Publisher · View at Google Scholar · View at Scopus
  7. F. Mojana, L. Cheng, D.-U. G. Bartsch et al., “The role of abnormal vitreomacular adhesion in age-related macular degeneration: spectral optical coherence tomography and surgical results,” American Journal of Ophthalmology, vol. 146, no. 2, pp. 218–227, 2008. View at Publisher · View at Google Scholar · View at Scopus
  8. S. J. Lee, C. S. Lee, and H. J. Koh, “Posterior vitreomacular adhesion and risk of exudative age-related macular degeneration: paired eye study,” The American Journal of Ophthalmology, vol. 147, no. 4, pp. 621.e1–626.e1, 2009. View at Publisher · View at Google Scholar · View at Scopus
  9. A. B. Roller, V. B. Mahajan, H. C. Boldt, M. D. Abramoff, S. R. Russell, and J. C. Folk, “Effects of vitrectomy on age-related macular degeneration,” Ophthalmology, vol. 117, no. 7, pp. 1381–1386, 2010. View at Publisher · View at Google Scholar · View at Scopus
  10. P. Fernández-Robredo, A. Sancho, S. Johnen et al., “Current treatment limitations in age-related macular degeneration and future approaches based on cell therapy and tissue engineering,” Journal of Ophthalmology, vol. 2014, Article ID 510285, 13 pages, 2014. View at Publisher · View at Google Scholar · View at Scopus
  11. F. G. Holz, W. Amoaku, J. Donate et al., “Safety and efficacy of a flexible dosing regimen of ranibizumab in neovascular age-related macular degeneration: the SUSTAIN study,” Ophthalmology, vol. 118, no. 4, pp. 663–671, 2011. View at Publisher · View at Google Scholar · View at Scopus
  12. A. Lux, H. Llacer, F. M. A. Heussen, and A. M. Joussen, “Non-responders to bevacizumab (Avastin) therapy of choroidal neovascular lesions,” The British Journal of Ophthalmology, vol. 91, no. 10, pp. 1318–1322, 2007. View at Publisher · View at Google Scholar · View at Scopus
  13. S. J. Lee and H. J. Koh, “Effects of vitreomacular adhesion on anti-vascular endothelial growth factor treatment for exudative age-related macular degeneration,” Ophthalmology, vol. 118, no. 1, pp. 101–110, 2011. View at Publisher · View at Google Scholar · View at Scopus
  14. G. Ö. Üney, N. Ünlü, M. A. Acar et al., “Role of posterior vitreous detachment on outcome of anti-vascular endothelial growth factor treatment in age-related macular degeneration,” Retina, vol. 34, no. 1, pp. 32–37, 2014. View at Publisher · View at Google Scholar · View at Scopus
  15. Y. Nomura, H. Takahashi, X. Tan, S. Fujimura, R. Obata, and Y. Yanagi, “Effects of vitreomacular adhesion on ranibizumab treatment in Japanese patients with age-related macular degeneration,” Japanese Journal of Ophthalmology, vol. 58, no. 5, pp. 443–447, 2014. View at Publisher · View at Google Scholar
  16. J. Sebag, “Vitreous: the resplendent enigma,” The British Journal of Ophthalmology, vol. 93, no. 8, pp. 989–991, 2009. View at Publisher · View at Google Scholar · View at Scopus
  17. P. N. Bishop, “Structural macromolecules and supramolecular organisation of the vitreous gel,” Progress in Retinal and Eye Research, vol. 19, no. 3, pp. 323–344, 2000. View at Publisher · View at Google Scholar · View at Scopus
  18. M. M. Le Goff and P. N. Bishop, “Adult vitreous structure and postnatal changes,” Eye, vol. 22, no. 10, pp. 1214–1222, 2008. View at Publisher · View at Google Scholar · View at Scopus
  19. E. Uchino, A. Uemura, and N. Ohba, “Initial stages of posterior vitreous detachment in healthy eyes of older persons evaluated by optical coherence tomography,” Archives of Ophthalmology, vol. 119, no. 10, pp. 1475–1479, 2001. View at Publisher · View at Google Scholar · View at Scopus
  20. J. S. Duker, P. K. Kaiser, S. Binder et al., “The international vitreomacular traction study group classification of vitreomacular adhesion, traction, and macular hole,” Ophthalmology, vol. 120, no. 12, pp. 2611–2619, 2013. View at Publisher · View at Google Scholar · View at Scopus
  21. A. R. H. Simpson, R. Petrarca, and T. L. Jackson, “Vitreomacular adhesion and neovascular age-related macular degeneration,” Survey of Ophthalmology, vol. 57, no. 6, pp. 498–509, 2012. View at Publisher · View at Google Scholar · View at Scopus
  22. M. Chen, J. V. Forrester, and H. Xu, “Dysregulation in retinal para-inflammation and age-related retinal degeneration in CCL2 or CCR2 deficient mice,” PLoS ONE, vol. 6, no. 8, Article ID e22818, 2011. View at Publisher · View at Google Scholar · View at Scopus
  23. R. Cascella, M. Ragazzo, C. Strafella et al., “Age-related macular degeneration: insights into inflammatory genes,” Journal of Ophthalmology, vol. 2014, Article ID 582842, 9 pages, 2014. View at Publisher · View at Google Scholar
  24. G. K. Hansson, P. Libby, U. Schönbeck, and Z.-Q. Yan, “Innate and adaptive immunity in the pathogenesis of atherosclerosis,” Circulation Research, vol. 91, no. 4, pp. 281–291, 2002. View at Publisher · View at Google Scholar · View at Scopus
  25. D.-Y. Yu, P. K. Yu, S. J. Cringle, M. H. Kang, and E.-N. Su, “Functional and morphological characteristics of the retinal and choroidal vasculature,” Progress in Retinal and Eye Research, vol. 40, pp. 53–93, 2014. View at Publisher · View at Google Scholar · View at Scopus
  26. M. T. Wong-Riley, “Energy metabolism of the visual system,” Eye and Brain, vol. 2, pp. 99–116, 2010. View at Publisher · View at Google Scholar
  27. F. Roth, A. Bindewald, and F. G. Holz, “Keypathophysiologic pathways in age-related macular disease,” Graefe's Archive for Clinical and Experimental Ophthalmology, vol. 242, no. 8, pp. 710–716, 2004. View at Publisher · View at Google Scholar · View at Scopus
  28. J. Fowles and E. Dybing, “Application of toxicological risk assessment principles to the chemical constituents of cigarette smoke,” Tobacco Control, vol. 12, no. 4, pp. 424–430, 2003. View at Publisher · View at Google Scholar · View at Scopus
  29. E. Stefánsson, “Physiology of vitreous surgery,” Graefe's Archive for Clinical and Experimental Ophthalmology, vol. 247, no. 2, pp. 147–163, 2009. View at Publisher · View at Google Scholar · View at Scopus
  30. P. K. Kaiser, C. D. Riemann, J. E. Sears, and H. Lewis, “Macular traction detachment and diabetic macular edema associated with posterior hyaloidal traction,” American Journal of Ophthalmology, vol. 131, no. 1, pp. 44–49, 2001. View at Publisher · View at Google Scholar · View at Scopus
  31. D. L. Nickla and J. Wallman, “The multifunctional choroid,” Progress in Retinal and Eye Research, vol. 29, no. 2, pp. 144–168, 2010. View at Publisher · View at Google Scholar · View at Scopus
  32. N. P. Blair, T. Liu, K. A. Warren et al., “Ocular oxygen consumption: estimates using vitreoperfusion in the cat,” Retina, vol. 24, no. 1, pp. 120–131, 2004. View at Publisher · View at Google Scholar · View at Scopus
  33. C. A. Wilson, J. D. Benner, B. A. Berkowitz, C. B. Chapman, and R. M. Peshock, “Transcorneal oxygenation of the preretinal vitreous,” Archives of Ophthalmology, vol. 112, no. 6, pp. 839–845, 1994. View at Publisher · View at Google Scholar · View at Scopus
  34. M. Šín, I. Šínová, O. Chrapek et al., “The effect of pars plan vitrectomy on oxygen saturation in retinal vessels—a pilot study,” Acta Ophthalmologica, vol. 92, no. 4, pp. 328–331, 2014. View at Publisher · View at Google Scholar · View at Scopus
  35. I. A. Barbazetto, J. Liang, S. Chang, L. Zheng, A. Spector, and J. P. Dillon, “Oxygen tension in the rabbit lens and vitreous before and after vitrectomy,” Experimental Eye Research, vol. 78, no. 5, pp. 917–924, 2004. View at Publisher · View at Google Scholar · View at Scopus
  36. A. R. H. Simpson, N. G. Dowell, T. L. Jackson, P. S. Tofts, and E. H. Hughes, “Measuring the effect of pars plana vitrectomy on vitreous oxygenation using magnetic resonance imaging,” Investigative Ophthalmology & Visual Science, vol. 54, no. 3, pp. 2028–2034, 2013. View at Publisher · View at Google Scholar · View at Scopus
  37. P. A. Quiram, V. R. Leverenz, R. M. Baker, L. Dang, F. J. Giblin, and M. T. Trese, “Microplasmin-induced posterior vitreous detachment affects vitreous oxygen levels,” Retina, vol. 27, no. 8, pp. 1090–1096, 2007. View at Publisher · View at Google Scholar · View at Scopus
  38. I. Krebs, C. Glittenberg, F. Zeiler, and S. Binder, “Spectral domain optical coherence tomography for higher precision in the evaluation of vitreoretinal adhesions in exudative age-related macular degeneration,” The British Journal of Ophthalmology, vol. 95, no. 10, pp. 1415–1418, 2011. View at Publisher · View at Google Scholar · View at Scopus
  39. D. F. Martin, M. G. Maguire, G.-S. Ying, J. E. Grunwald, S. L. Fine, and G. J. Jaffe, “Ranibizumab and bevacizumab for neovascular age-related macular degeneration,” The New England Journal of Medicine, vol. 364, no. 20, pp. 1897–1908, 2011. View at Publisher · View at Google Scholar · View at Scopus
  40. T. L. Jackson, R. P. Danis, M. Goldbaum et al., “Retinal vascular abnormalities in neovascular age-related macular degeneration,” Retina, vol. 34, no. 3, pp. 568–575, 2014. View at Publisher · View at Google Scholar · View at Scopus
  41. L. P. Aiello, R. L. Avery, P. G. Arrigg et al., “Vascular endothelial growth factor in ocular fluid of patients with diabetic retinopathy and other retinal disorders,” The New England Journal of Medicine, vol. 331, no. 22, pp. 1480–1487, 1994. View at Publisher · View at Google Scholar · View at Scopus
  42. P. N. Bishop, D. F. Holmes, K. E. Kadler, D. McLeod, and K. J. Bos, “Age-related changes on the surface of vitreous collagen fibrils,” Investigative Ophthalmology & Visual Science, vol. 45, no. 4, pp. 1041–1046, 2004. View at Publisher · View at Google Scholar · View at Scopus
  43. A. B. Reese, I. S. Jones, and W. C. Cooper, “Macular changes secondary to vitreous traction,” American Journal of Ophthalmology, vol. 64, no. 3, pp. 544–549, 1967. View at Google Scholar · View at Scopus
  44. I. Suzuma, Y. Hata, A. Clermont et al., “Cyclic stretch and hypertension induce retinal expression of vascular endothelial growth factor and vascular endothelial growth factor receptor-2: potential mechanisms for exacerbation of diabetic retinopathy by hypertension,” Diabetes, vol. 50, no. 2, pp. 444–454, 2001. View at Publisher · View at Google Scholar · View at Scopus
  45. H. Kinoshita, K. Suzuma, T. Maki et al., “Cyclic stretch and hypertension increase retinal succinate: potential mechanisms for exacerbation of ocular neovascularization by mechanical stress,” Investigative Ophthalmology & Visual Science, vol. 55, no. 7, pp. 4320–4326, 2014. View at Publisher · View at Google Scholar
  46. I. Suzuma, K. Suzuma, K. Ueki et al., “Stretch-induced retinal vascular endothelial growth factor expression is mediated by phosphatidylinositol 3-kinase and protein kinase C (PKC)-ζ but not by stretch-induced ERK1/2, Akt, Ras, or classical/novel PKC pathways,” The Journal of Biological Chemistry, vol. 277, no. 2, pp. 1047–1057, 2002. View at Publisher · View at Google Scholar · View at Scopus
  47. T. L. Jackson, E. Nicod, A. Angelis et al., “Vitreous attachment in age-related macular degeneration, diabetic macular edema, and retinal vein occlusion: a systematic review and metaanalysis,” Retina, vol. 33, no. 6, pp. 1099–1108, 2013. View at Publisher · View at Google Scholar · View at Scopus
  48. U. Mayr-Sponer, S. M. Waldstein, M. Kundi et al., “Influence of the vitreomacular interface on outcomes of ranibizumab therapy in neovascular age-related macular degeneration,” Ophthalmology, vol. 120, no. 12, pp. 2620–2629, 2013. View at Publisher · View at Google Scholar · View at Scopus
  49. S. M. Waldstein, M. Ritter, C. Simader, U. Mayr-Sponer, M. Kundi, and U. Schmidt-Erfurth, “Impact of vitreomacular adhesion on ranibizumab mono- and combination therapy for neovascular age-related macular degeneration,” American Journal of Ophthalmology, vol. 158, no. 2, pp. 328.e1–336.e1, 2014. View at Google Scholar · View at Scopus
  50. T. A. Cuilla, G. S. Ying, M. G. Maguire et al., “Influence of the vitreomacular interface on treatment outcomes in the comparison of age-related macular degeneration treatments trials,” Ophthalmology, vol. 122, no. 6, pp. 1203–1211, 2015. View at Publisher · View at Google Scholar
  51. U. Chakravarthy, S. P. Harding, C. A. Rogers et al., “Alternative treatments to inhibit VEGF in age-related choroidal neovascularisation: 2-year findings of the IVAN randomised controlled trial,” The Lancet, vol. 382, no. 9900, pp. 1258–1267, 2013. View at Publisher · View at Google Scholar · View at Scopus
  52. T. Ikeda, H. Sawa, K. Koizumi, T. Yasuhara, and T. Yamasaki, “Pars plana vitrectomy for regression of choroidal neovascularization with agerelated macular degeneration,” Acta Ophthalmologica Scandinavica, vol. 78, no. 4, pp. 460–464, 2000. View at Publisher · View at Google Scholar · View at Scopus
  53. Y.-L. Liu, C.-P. Lin, and C.-M. Yang, “Transient regression of choroidal neovascularization membrane after vitrectomy in age-related macular degeneration with vitreomacular traction syndrome,” Acta Ophthalmologica, vol. 89, no. 3, pp. e291–e293, 2011. View at Publisher · View at Google Scholar · View at Scopus
  54. S. U. Shah and J. A. Haller, “Vitreomacular traction in a case of exudative age-related macular degeneration resistant to anti-VEGF therapy,” Acta Ophthalmologica, vol. 90, no. 7, pp. e569–e570, 2012. View at Publisher · View at Google Scholar · View at Scopus
  55. T. Sakamoto, S.-J. Sheu, N. Arimura et al., “Vitrectomy for exudative age-related macular degeneration with vitreous hemorrhage,” Retina, vol. 30, no. 6, pp. 856–864, 2010. View at Publisher · View at Google Scholar · View at Scopus
  56. K. Schramm, M. Mueller, F. H. Koch, P. Singh, T. Kohnen, and M. J. Koss, “Effects of core vitrectomy in the treatment of age-related macular degeneration,” Acta Ophthalmologica, vol. 92, no. 5, pp. 465–472, 2014. View at Publisher · View at Google Scholar · View at Scopus
  57. E. W. Schneider and M. W. Johnson, “Emerging nonsurgical methods for the treatment of vitreomacular adhesion: a review,” Clinical Ophthalmology, vol. 5, no. 1, pp. 1151–1165, 2011. View at Google Scholar · View at Scopus
  58. Y. Y. Syed and S. Dhillon, “Ocriplasmin: a review of its use in patients with symptomatic vitreomacular adhesion,” Drugs, vol. 73, no. 14, pp. 1617–1625, 2013. View at Publisher · View at Google Scholar · View at Scopus
  59. P. Stalmans, M. S. Benz, A. Gandorfer et al., “Enzymatic vitreolysis with ocriplasmin for vitreomacular traction and macular holes,” The New England Journal of Medicine, vol. 367, no. 7, pp. 606–615, 2012. View at Publisher · View at Google Scholar · View at Scopus
  60. J. A. Haller, P. Stalmans, M. S. Benz et al., “Efficacy of intravitreal ocriplasmin for treatment of vitreomacular adhesion: subgroup analyses from two randomized trials,” Ophthalmology, vol. 122, no. 1, pp. 117–122, 2015. View at Publisher · View at Google Scholar
  61. R. L. Novack, G. Staurenghi, A. Girach, N. Narendran, and M. Tolentino, “Safety of intravitreal ocriplasmin for focal vitreomacular adhesion in patients with exudative age-related macular degeneration,” Ophthalmology, vol. 122, no. 4, pp. 796–802, 2015. View at Publisher · View at Google Scholar
  62. M. Gross-Jendroska, C. J. Flaxel, S. D. Schwartz et al., “Treatment of pigment epithelial detachments due to age-related macular degeneration with intra-ocular C3F8 injection,” Australian and New Zealand Journal of Ophthalmology, vol. 26, no. 4, pp. 311–317, 1998. View at Publisher · View at Google Scholar · View at Scopus
  63. Y. M. Kim, S. J. Lee, and H. J. Koh, “Gas-assisted release of vitreomacular adhesion in wet age-related macular degeneration,” Retina, vol. 31, no. 10, pp. 2123–2124, 2011. View at Publisher · View at Google Scholar · View at Scopus
  64. I. A. Rodrigues, A. N. Stangos, D. A. McHugh, and T. L. Jackson, “Intravitreal injection of expansile perfluoropropane (c(3)f(8)) for the treatment of vitreomacular traction,” The American Journal of Ophthalmology, vol. 155, no. 2, pp. 270.e2–276.e2, 2013. View at Publisher · View at Google Scholar
  65. D. McHugh, B. Gupta, and M. Saeed, “Intravitreal gas injection for the treatment of diabetic macular edema,” Clinical Ophthalmology, vol. 5, no. 1, pp. 1543–1548, 2011. View at Google Scholar · View at Scopus
  66. G. Seymenoglu, O. Kayikcioglu, and B. O. Sahin, “Resolution of vitreomacular traction following intravitreal triamcinolone acetonide injection in an eye with branch retinal vein occlusion,” Clinical Ophthalmology (Auckland, N.Z.), vol. 6, pp. 1239–1243, 2012. View at Google Scholar
  67. H. Kerimoglu, B. T. Ozturk, B. Bozkurt, M. Okka, and S. Okudan, “Does lens status affect the course of early intraocular pressure and anterior chamber changes after intravitreal injection?” Acta Ophthalmologica, vol. 89, no. 2, pp. 138–142, 2011. View at Publisher · View at Google Scholar · View at Scopus