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Journal of Ophthalmology
Volume 2016, Article ID 1287847, 10 pages
Research Article

Pilot Study on Visual Function and Fundus Autofluorescence Assessment in Diabetic Patients

1Optometry Research Group, Department of Optics & Optometry & Vision Sciences, University of Valencia, Burjassot, 46100 Valencia, Spain
2Department of Ophthalmology, Oftalmar, Medimar International Hospital, 03016 Alicante, Spain

Received 22 September 2015; Revised 10 January 2016; Accepted 13 January 2016

Academic Editor: Xinjian Chen

Copyright © 2016 Ana M. Calvo-Maroto et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Purpose. Evaluate optimized fundus autofluorescence (FAF) imaging in early stages of diabetic retinopathy (DR) and relate findings with conventional colour fundus imaging and visual function in diabetic patients and control subjects. Materials and Methods. FAF and colour images were obtained using the CR-2 Plus digital nonmydriatic retinal camera in seven diabetic patients and thirteen control subjects. Visual-Functioning Questionnaire-25 (VFQ-25) and Diabetes Self-Management Questionnaire (DSMQ) were used to assess the quality of life and diabetes self-care. Contrast sensitivity function (CSF) was evaluated with the Vistech 6500 chart. Results. FAF and optimized-FAF imaging showed more retinal alterations related to DR than colour imaging. In diabetic patients, compatible signs with microaneurysms, capillary dilations, and haemorrhages were less numerous in colour imaging than optimized-FAF and FAF imaging in areas analysed. Control subjects at risk of developing DM showed more retinal pigment epithelium defects than those without risk in all retinal areas. Significant differences were not found in VFQ-25 and CSF between diabetic patients and control subjects. Conclusions. FAF and optimized-FAF imaging showed significant alterations related to DR not observed in colour imaging. FAF and optimized-FAF images could be a useful complementary tool for detecting early alterations associated with the development and progression of DR.