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Journal of Ophthalmology
Volume 2016, Article ID 1348347, 11 pages
Research Article

Association of Common Variants in eNOS Gene with Primary Open Angle Glaucoma: A Meta-Analysis

Yang Xiang,1 Yi Dong,1,2 Xuan Li,1,2,3,4 and Xin Tang1,2,3,4

1Clinical College of Ophthalmology, Tianjin Medical University, 4 Gansu Road, Tianjin 300020, China
2Tianjin Eye Hospital, 4 Gansu Road, Tianjin 300020, China
3Tianjin Key Laboratory of Ophthalmology and Visual Science, 4 Gansu Road, Tianjin 300020, China
4Tianjin Eye Institute, 4 Gansu Road, Tianjin 300020, China

Received 22 February 2016; Accepted 12 April 2016

Academic Editor: Hermann Mucke

Copyright © 2016 Yang Xiang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Purpose. To clarify the association of endothelial nitric oxide synthase (eNOS) polymorphisms and primary open angle glaucoma (POAG). Methods. After a systematic literature search in the MEDLINE, EMBASE, and ISI Web of Science databases, all relevant studies evaluating the association between the polymorphisms (rs2070744 and rs1799983) of eNOS gene and POAG were screened and included. The pooled odds ratios (ORs) and the 95% confidence interval (CI) of each single-nucleotide polymorphism (SNP) in five genetic models were estimated using fixed-effect model if in the test for heterogeneity; otherwise the random-effects model was used. Results. Thirty-one records were obtained, with five being suitable for meta-analysis. The overall results showed that both TT genotype in rs2070744 and GG genotype in rs1799983 are associated with decreased risk of POAG susceptibility. Stratified analysis based on ethnicity showed that the association of rs2070744 with POAG remained only in Caucasians. Results of subgroup analysis by sex indicated association between both polymorphisms and POAG in female group, but not in male group. Conclusions. TT genotype and/or T-allele in rs2070744, as well as GG genotype and/or G-allele in rs1799983, was associated with decreased risk for POAG overall and in female group.