Association of Common Variants in eNOS Gene with Primary Open Angle Glaucoma: A Meta-Analysis

Table 1

Principle characteristics of the studies included in the meta-analysis for association between eNOS rs2070744 and POAG.

First author	Cohorts	Year	Ethnicity	Genotyping	Case					Control					Control
					Size	GG	GA	AA	MAF	Size	GG	GA	AA	MAF	HWE ()
Fan [16]	All	2010	Asians	NA	397	319	72	6	0.11	201	157	43	1	0.11	0.44
Kang [17]	All	2011	Caucasians	Taqman	510	236	203	71	0.34	1444	682	598	164	0.32	0.28
	Male	2011	Caucasians	Taqman	147	72	60	15	0.31	425	203	170	52	0.32	0.06
	Female	2011	Caucasians	Taqman	363	164	143	56	0.35	1019	479	428	112	0.32	0.08
Magalhães da Silva [18]	All	2012	Caucasians	Taqman	89	55	27	7	0.23	124	72	46	6	0.23	0.28
	Male	2012	Caucasians	Taqman	28	20	7	1	0.16	63	35	24	4	0.25	0.70
	Female	2012	Caucasians	Taqman	61	35	22	4	0.25	61	37	23	1	0.20	0.97
Emam [19]	All	2014	Caucasians	PCR-RFLP	160	81	59	20	0.31	110	63	37	10	0.26	0.22
	Male	2014	Caucasians	PCR-RFLP	76	41	24	11	0.11	56	32	19	5	0.11	0.19
	Female	2014	Caucasians	PCR-RFLP	84	40	35	9	0.34	54	31	18	5	0.32	0.39

NA: data not available; MAF: Minor Allele Frequency; HWE: Hardy-Weinberg equilibrium; PCR-RFLP: polymerase chain reaction-restriction fragment length polymorphism.