Association of Common Variants in eNOS Gene with Primary Open Angle Glaucoma: A Meta-Analysis

Table 4

Summary risk estimates for association between eNOS rs1799983 and POAG.

	Comparisons	Studies ()	Model	Pooled estimate; OR (95% CI)		Heterogeneity; (%)		Egger’s; test	Begg’s; test (
Overall	G versus A	4	F	0.928 (0.817–1.053)	0.247	0.0	0.694	0.851	0.734
	GG versus AA	4	F	0.753 (0.568–0.997)	0.048	0.0	0.831	0.039	0.308
	GA versus AA	4	F	0.745 (0.559–0.993)	0.045	0.0	0.720	0.149	0.089
	GG + GA versus AA	4	F	0.752 (0.576–0.983)	0.037	0.0	0.824	0.033	0.089
	GG versus GA + AA	4	F	0.979 (0.832–1.153)	0.803	0.0	0.584	0.832	1.000
Female	G versus A	3	F	0.852 (0.724–1.003)	0.054	0.0	0.869
	GG versus AA	3	F	0.665 (0.471–0.938)	0.020	0.0	0.651
	GA versus AA	3	F	0.674 (0.474–0.958)	0.028	0.0	0.505
	GG + GA versus AA	3	F	0.666 (0.481–0.923)	0.015	0.0	0.626
	GG versus GA + AA	3	F	0.894 (0.720–1.108)	0.306	0.0	0.684
Male	G versus A	3	F	1.067 (0.839–1.358)	0.595	20.7	0.283
	GG versus AA	3	F	1.085 (0.641–1.836)	0.124	0.0	0.431
	GA versus AA	3	F	1.041 (0.604–1.793)	0.885	0.0	0.557
	GG + GA versus AA	3	F	1.066 (0.643–1.768)	0.804	0.0	0.456
	GG versus GA + AA	3	F	1.088 (0.798–1.485)	0.593	0.0	0.378
Asians	G versus A	1	—	1.065 (0.726–1.564)	0.746	—	—
	GG versus AA	1	—	0.339 (0.040–2.837)	0.682	—	—
	GA versus AA	1	—	0.279 (0.032–2.397)	0.245	—	—
	GG + GA versus AA	1	—	0.326 (0.039–2.725)	0.301	—	—
	GG versus GA + AA	1	—	1.146 (0.756–1.737)	0.520	—	—
Caucasians	G versus A	3	F	0.912 (0.797–1.043)	0.180	0.0	0.641
	GG versus AA	3	F	0.768 (0.578–1.021)	0.069	0.0	0.855
	GA versus AA	3	F	0.765 (0.572–1.023)	0.071	0.0	0.776
	GG + GA versus AA	3	F	0.767 (0.585–1.006)	0.055	0.0	0.866
	GG versus GA + AA	3	F	0.952 (0.798–1.137)	0.803	0.0	0.584

OR: odds ratio; CI: confidence interval; : value for test; : value for -test; F: fixed-effects mode; —: data not available.