Accelerated Corneal Collagen Cross-Linking Using Topography-Guided UV-A Energy Emission: Preliminary Clinical and Morphological Outcomes

Figure 4

Corneal OCT following high-irradiance topography-guided CXL. At 3rd postoperative month (a), multiple demarcation lines due to the different energy doses delivered according to the topography-guided CXL protocol were evident. (b) illustrates the topography-guided treatment in progress. (c) shows the topo-guided treatment planning with programmed double energy dose: 7.2 J/cm² in the flattest area under 48 D (yellow arrow) with arc-step pattern, and 10 J/cm² in the steepest central area over 48 D (red arrow) with circular pattern. (d) shows the 12th month postoperative flattening compared with preoperative tomography (e), followed by compensatory steepening of the flattest superior cornea documented in differential corneal tomography (f).