Accelerated Corneal Collagen Cross-Linking Using Topography-Guided UV-A Energy Emission: Preliminary Clinical and Morphological Outcomes

Table 1

Inclusion criteria and treatment protocol.

Keratoconus progression criteria	Increased sim  ≥ 1 D; pachymetry reduction ≥ 10 µm
Procedure	Epithelium removal, 10-minute soaking with VibeX Rapid 0.1 riboflavin, saline, HPMC solution applied every 90 seconds
Irradiance	30 mW/cm^2 pulsed or fractionated UVA light exposure (1 second on/1 second off)
Energy	From 7.2 J/cm^2 up to 15 J/cm^2 total energy dose
Patterns	Arc patterns for “peripheral cones” (apex distance ≥3 mm from the pupillary center); circular patterns for “central cones”
Thickness	Minimum stromal thickness 400 µm