Zeaxanthin: Review of Toxicological Data and Acceptable Daily Intake

Table 3

Effects on reproduction data in the zeaxanthin two-generation study in rats [31].

Nominal dosage (mg/kg bw/day)	0	0; (placebo)	50	150	500
F1 generation
Adults, mating index %	100.0	100.0	96.0	96.0	79.3
Mean number of pups:
born	10.2	10.9	10.7	10.7	9.7
alive day 4 postpartum; (before culling)	10.0	10.9	10.5	10.5	9.7
P generation
% pup weight gain
Days 4–7 postpartum	62.3	62.0	64.2	61.6	59.3
Days 1–21 postpartum	774.7	753.3	780.9	755.0	725.3
F1 generation
% pup weight gain
Days 4–7 postpartum	64.4	62.8	60.5	61.3	58.1
Days 1–21 postpartum	738.9	745.1	713.5	724.9	695.0

= Cochran-Armitage and Fisher’s exact test.
= dose response test, Kruskal-Wallis, Terpstra-Jonckheere, and Wilcoxon.
; .