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Journal of Ophthalmology
Volume 2016, Article ID 4235923, 9 pages
Research Article

Ultrasound Microbubbles Enhance the Neuroprotective Effect of Mouse Nerve Growth Factor on Intraocular Hypertension-Induced Neuroretina Damage in Rabbits

1Affiliated Shenzhen Eye Hospital of Jinan University, Shenzhen, Guangdong, China
2Shenzhen Key Laboratory of Ophthalmology, Shenzhen, Guangdong Province, China
3School of Ophthalmology & Optometry Affiliated to Shenzhen University, Shenzhen, Guangdong, China
4Shenzhen People’s Hospital, Shenzhen, Guangdong, China
5Shenzhen University, Shenzhen, Guangdong, China

Received 22 June 2016; Revised 30 September 2016; Accepted 10 October 2016

Academic Editor: Flavio Mantelli

Copyright © 2016 Xiaoli Shen et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Ultrasound microbubble combined optic protection drugs have obvious protective effect on optic nerve damage. This way of targeting drug delivery is becoming more simple, not through the whole body metabolism, avoiding drug via blood circulation when facing the decomposition and the environment in the interference and destruction process of drugs, to maximize the guarantee to reach target organs of drug concentration and to reache the maximum therapeutic effect. The technique of ultrasound microbubbles is safe, controllable, nonimmunogenic, and repeatable. It provides us with a novel idea in the administration of neuroprotective drugs.