Ultrasound Microbubbles Enhance the Neuroprotective Effect of Mouse Nerve Growth Factor on Intraocular Hypertension-Induced Neuroretina Damage in Rabbits

Figure 2

Histopathological structure of the retina. (a) Retinal ganglion cells presented single permutation with large, round, or oval nucleus but without vacuolar degeneration. Inner plexiform layer was thick with net-like structure (Muller cells inside). Outer plexiform layer was thinner than inner plexiform layer. In outer nuclear layer, nuclei were dark dyeing, compactly arranged. (b) Each layer of retina had structural distortion, lacking unity and coherence. Retinal ganglion cells decreased in number, with obvious vacuolar degeneration. Inner plexiform layer and outer plexiform layer became thinner. In inner nuclear layer, nuclei were shallow dyeing, loosely arranged. ((c), (d)) Each layer of retina was distinct and arranged orderly, relatively. Number of retinal ganglion cells was higher than that in group B. Sporadic vacuolar degeneration could still be seen in retinal ganglion cells. Inner plexiform layer and outer plexiform layer became thinner as well. In inner and outer nuclear layer, nuclei were less dyeing, loosely arranged. (e) Each layer of retina was clear and arranged orderly. Number of retinal ganglion cells was higher than that in groups C and D. Little vacuolar degeneration could be seen in retinal ganglion cells. The thickness of inner plexiform layer and outer plexiform layer was nearly in normal range. In inner and outer nuclear layer, nuclei were less dyeing, loosely arranged.

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