Table of Contents Author Guidelines Submit a Manuscript
Journal of Ophthalmology
Volume 2016 (2016), Article ID 5072781, 7 pages
http://dx.doi.org/10.1155/2016/5072781
Research Article

Expression of TSLP and Downstream Molecules IL-4, IL-5, and IL-13 on the Eye Surface of Patients with Various Types of Allergic Conjunctivitis

Department of Corneal Diseases, Shanxi Eye Hospital, Fu Dong Street No. 100, Xinghualing District, Taiyuan City, Shanxi Province, China

Received 12 March 2016; Accepted 17 June 2016

Academic Editor: George M. Saleh

Copyright © 2016 Xiaofen Zheng et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. Z. Liu, Y. Yao, and B. Sun, “The clinical characteristics of allergic conjunctivitis,” Chinese Journal of Practical Ophthalmology, vol. 22, pp. 694–697, 2004. View at Google Scholar
  2. S. Bonini, M. Coassin, S. Aronni, and A. Lambiase, “Vernal keratoconjunctivitis,” Eye, vol. 18, no. 4, pp. 345–351, 2004. View at Publisher · View at Google Scholar · View at Scopus
  3. S. Bonini, “Atopic keratoconjunctivitis,” Allergy, vol. 59, no. 78, supplement, pp. 71–73, 2004. View at Publisher · View at Google Scholar · View at Scopus
  4. L. S. Park, U. Martin, K. Garka et al., “Cloning of the murine thymic stromal lymphopoietin (TSLP) receptor: formation of a functional heteromeric complex requires interleukin 7 receptor,” The Journal of Experimental Medicine, vol. 192, no. 5, pp. 659–670, 2000. View at Publisher · View at Google Scholar · View at Scopus
  5. G. R. Melum, L. Farkas, C. Scheel et al., “A thymic stromal lymphopoietin-responsive dendritic cell subset mediates allergic responses in the upper airway mucosa,” The Journal of Allergy and Clinical Immunology, vol. 134, no. 3, pp. 613–621.e7, 2014. View at Publisher · View at Google Scholar · View at Scopus
  6. Y.-J. Liu, “Thymic stromal lymphopoietin and OX40 ligand pathway in the initiation of dendritic cell-mediated allergic inflammation,” Journal of Allergy and Clinical Immunology, vol. 120, no. 2, pp. 238–246, 2007. View at Publisher · View at Google Scholar · View at Scopus
  7. Y.-J. Liu, V. Soumelis, N. Watanabe et al., “TSLP: an epithelial cell cytokine that regulates t cell differentiation by conditioning dendritic cell maturation,” Annual Review of Immunology, vol. 25, pp. 193–219, 2007. View at Publisher · View at Google Scholar · View at Scopus
  8. Y.-H. Wang and Y.-J. Liu, “OX40-OX40L interactions: a promising therapeutic target for allergic diseases?” The Journal of Clinical Investigation, vol. 117, no. 12, pp. 3655–3657, 2007. View at Publisher · View at Google Scholar · View at Scopus
  9. Y.-H. Wang, T. Ito, Y.-H. Wang et al., “Maintenance and polarization of human TH2 central memory T cells by thymic stromal lymphopoietin-activated dendritic cells,” Immunity, vol. 24, no. 6, pp. 827–838, 2006. View at Publisher · View at Google Scholar · View at Scopus
  10. P. Ma, F. Bian, Z. Wang et al., “Human corneal epithelium-derived thymic stromal lymphopoietin links the innate and adaptive immune responses via TLRs and Th2 cytokines,” Investigative Ophthalmology and Visual Science, vol. 50, no. 6, pp. 2702–2709, 2009. View at Publisher · View at Google Scholar · View at Scopus
  11. X. Zheng, P. Ma, C. S. de Paiva et al., “TSLP and downstream molecules in experimental mouse allergic conjunctivitis,” Investigative Ophthalmology and Visual Science, vol. 51, no. 6, pp. 3076–3082, 2010. View at Publisher · View at Google Scholar · View at Scopus
  12. D.-Q. Li, L. Zhang, S. C. Pflugfelder et al., “Short ragweed pollen triggers allergic inflammation through Toll-like receptor 4-dependent thymic stromal lymphopoietin/OX40 ligand/OX40 signaling pathways,” Journal of Allergy and Clinical Immunology, vol. 128, no. 6, pp. 1318–1325, 2011. View at Publisher · View at Google Scholar · View at Scopus
  13. A. Matsuda, N. Ebihara, N. Yokoi et al., “Functional role of thymic stromal lymphopoietin in chronic allergic keratoconjunctivitis,” Investigative Ophthalmology & Visual Science, vol. 51, no. 1, pp. 151–155, 2010. View at Publisher · View at Google Scholar · View at Scopus
  14. A. Leonardi, E. Bogacka, J. L. Fauquert et al., “Ocular allergy: recognizing and diagnosing hypersensitivity disorders of the ocular surface,” Allergy, vol. 67, no. 11, pp. 1327–1337, 2012. View at Publisher · View at Google Scholar · View at Scopus
  15. S. Liu, Introduction to Immunology, People's Health Publishing Press, Beijing, China, 2003.
  16. M. Dinowitz, R. Rescigno, and L. Bielory, “Ocular allergic diseases: differential diagnosis, examination techniques, and testing,” Clinical Allergy and Immunology, vol. 15, pp. 127–150, 2000. View at Google Scholar · View at Scopus
  17. H.-S. Kim, X. J. Song, C. S. De Paiva, Z. Chen, S. C. Pflugfelder, and D.-Q. Li, “Phenotypic characterization of human corneal epithelial cells expanded ex vivo from limbal explant and single cell cultures,” Experimental Eye Research, vol. 79, no. 1, pp. 41–49, 2004. View at Publisher · View at Google Scholar · View at Scopus
  18. D.-Q. Li and S. C. G. Tseng, “Three patterns of cytokine expression potentially involved in epithelial-fibroblast interactions of human ocular surface,” Journal of Cellular Physiology, vol. 163, no. 1, pp. 61–79, 1995. View at Publisher · View at Google Scholar · View at Scopus
  19. Z. Chen, C. S. De Paiva, L. Luo, F. L. Kretzer, S. C. Pflugfelder, and D.-Q. Li, “Characterization of putative stem cell phenotype in human limbal epithelia,” Stem Cells, vol. 22, no. 3, pp. 355–366, 2004. View at Publisher · View at Google Scholar · View at Scopus
  20. B. Lowe, H. A. Avila, F. R. Bloom, M. Gleeson, and W. Kusser, “Quantitation of gene expression in neural precursors by reverse-transcription polymerase chain reaction using self-quenched, fluorogenic primers,” Analytical Biochemistry, vol. 315, no. 1, pp. 95–105, 2003. View at Publisher · View at Google Scholar · View at Scopus
  21. K.-C. Yoon, C. S. De Paiva, H. Qi et al., “Expression of Th-1 chemokines and chemokine receptors on the ocular surface of C57BL/6 mice: effects of desiccating stress,” Investigative Ophthalmology and Visual Science, vol. 48, no. 6, pp. 2561–2569, 2007. View at Publisher · View at Google Scholar · View at Scopus
  22. C. S. De Paiva, R. M. Corrales, A. L. Villarreal et al., “Corticosteroid and doxycycline suppress MMP-9 and inflammatory cytokine expression, MAPK activation in the corneal epithelium in experimental dry eye,” Experimental Eye Research, vol. 83, no. 3, pp. 526–535, 2006. View at Publisher · View at Google Scholar · View at Scopus
  23. D. Hannouche and T. Hoangxuan, Inflammatory Diseases of the Conjunctiva, Srettgart, New York, NY, USA, 2001.
  24. S. A. Dunbar, C. A. Vander Zee, K. G. Oliver, K. L. Karem, and J. W. Jacobson, “Quantitative, multiplexed detection of bacterial pathogens: DNA and protein applications of the Luminex LabMAP system,” Journal of Microbiological Methods, vol. 53, no. 2, pp. 245–252, 2003. View at Publisher · View at Google Scholar · View at Scopus
  25. A. Inic-Kanada, A. Nussbaumer, J. Montanaro et al., “Comparison of ophthalmic sponges and extraction buffers for quantifying cytokine profiles in tears using luminex technology,” Molecular Vision, vol. 18, pp. 2717–2725, 2012. View at Google Scholar · View at Scopus