Retinal Electrophysiology Is a Viable Preclinical Biomarker for Drug Penetrance into the Central Nervous System

Figure 1

Retinal electrophysiology following conscious isoguvacine/muscimol dosing. ERG responses in conscious animals ((a)–(d), for each drug group) at baseline (black lines, average of vehicle injections in both conscious groups) compared to (a) intramuscular and (b) intravitreal injection of isoguvacine (red) and (c) intramuscular and (d) intravitreal injection of muscimol (blue). (e)–(h) summarise ERG parameters (average ± SEM) following isoguvacine or muscimol injections via the different delivery routes (see method for details). Grey areas indicate 95% CI of the particular ERG parameter in all conscious baseline recordings. .